The title compound, C8H13N2O + H2PO4, is an ionic salt. The organic species is protonated at the N atom of the dimethylaminomethyl group. The dihydrogenphosphate moieties are connected into in®nite chains by way of OÐH O links. The H2PO4 ÿ group also makes an OÐH N hydrogen bond to the pyridine N atom of the organic species. The organic cations crosslink the phosphate chains into a three-dimens...

A rapid, precise, economical, and accurate HPLC method for estimation of Ibutilide fumarate in bulk and formulations was developed and validated via system suitability method. The chromatographic resolution of Ibutilide was achieved using acetonitrile: 0.1M ammonium dihydrogen phosphate buffer PH~ 6(Phasphoricacid), (25: 75 V/V) as a mobile phase UV detection at 250 nm and Hypersil thermo C18 c...

Phosphosulfonic  acid  as a  multi  solid site  was  easily  prepared  from  the reaction of ammonium  dihydrogen phosphate with chlorosulfonic acid in CCl4and for improved  its  catalytic activity  was  supported  nano Silica was  extracted from  husk  rice  contains  about 95%  of  Silica the  size of  extracted nano silica was  determined  by  SEM  efficiency of  this solid acid in four comp...

A simple, rapid and sensitive high-performance liquid chromatographic (HPLC) method for the determination of risperidone in human plasma was developed. An HPLC system based on a Nucleosil C8 column (150?4 mm) and a UV detector (?= 280 nm) were used. A mixture of sodium dihydrogen phosphate buffer-acetonitrile (55:45, v/v) adjusted to pH 6.0 at a flow rate of 1.5 ml min-1 was used as mobile phas...

A simple, rapid and sensitive high-performance liquid chromatographic (HPLC) method for the determination of risperidone in human plasma was developed. An HPLC system based on a Nucleosil C8 column (150?4 mm) and a UV detector (?= 280 nm) were used. A mixture of sodium dihydrogen phosphate buffer-acetonitrile (55:45, v/v) adjusted to pH 6.0 at a flow rate of 1.5 ml min-1 was used as mobile phas...

A rapid, sensitive and reproducible HPLC method using amperometric detector was developed and validated for the analysis of clarithromycin in human plasma. The separation was achieved on a monolithic silica column (MZ- C8 125×4.0 mm) using acetonitrile- methanol-potassium dihydrogen phosphate buffer (40:6:54,v/v), with pH of 7.5, as the mobile phase at a flow rate of 1.5 mL/min. The assay enabl...

A simple, sensitive, and inexpensive high-performance liquid-chromatographic method has been developed for simultaneous determination of hydrochlorothiazide and candesartan cilexetil in pharmaceutical formulations. Chromatographic separation was achieved on a Phenyl-2 column with a 25:75:0.2 mixture of 0.02 M potassium dihydrogen phosphate, methanol, and triethylamine, final pH 6.0 ± 0.1, as mo...

Received: April 12, 2011 / Revised: April 17, 2011 / Accepted: April 18, 2011 A simple and precise RP‐HPLC method was developed and validated for the determination of acetyl sulfisoxazole in blood samples. Chromatography was carried out using methanol:acetonitrile:0.01M potassium dihydrogen phosphate (25:50:25 v/v) as the mobile phase at a flow rate 1.2 ml/min. The analyte was monitored by usin...