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•Construction of an antibody response landscape against SARS-CoV-2 proteome•Non-structural/accessory proteins elicit prevalent responses•IgG non-structural/accessory is more associated with disease severity•For non-survivors, levels IgG S1 and N decline significantly before death The immunogenicity the proteome largely unknown, especially for non-structural accessory proteins. In this study, we...
conclusions according to the results, the iranian public health centers preparedness against disasters before, during and after accidents were in safety level 4 from 10, which was undesirable. results risk rate, functional, non-structural and structural preparedness and final safety level were 58.62%, 51.48%, 54.82%, 33.97%, and 43.72%, respectively. background ahvaz metropolitan as an industri...
Site-Specific PEGylation of Recombinant Immunotoxin DAB389IL-2: Structural and Functional Assessment
Background: DAB389IL-2 is considered a fusion immunotoxin and it is used for the CTCL therapy. DAB389IL-2 includes of two distinct portions; the catalytic domain of diphtheria toxin and IL-2. DAB389IL-2 duo to the presence of a free cysteine residue (Cys 513 in IL-2 part) is prone to unwanted intramolecular and intermolecular disulfide bonds formation and aggregation problems. Aggregation is co...
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