The fact that oxidation, as one of the main routes of phase I metabolism of drugs, follows by conjugation reactions, and also formation of nitrenium ion as one of the clozapine oxidation products, directed us to investigate the oxidation of clozapine (CLZ) in the presence of nucleophile. The oxidation of clozapine (CLZ) has been studied on a glassy carbon electrode in the absence and presence o...

BACKGROUND Several studies have evaluated the oxidant and antioxidant status of thalassemia patients but most focused mainly on the severe and intermediate states of the disease. Moreover, the oxidative status has not been evaluated for the different beta-thalassemia mutations. OBJECTIVE To evaluate lipid peroxidation and Trolox equivalent antioxidant capacity in relation to serum iron and fe...

Experimental resu!ts reported in the literature suggest that tumour cells are under oxidative stress, both as a consequence of their altered biochemistry and of the tumour environment. Unfortunately, tumour cells are able to resist this oxidative stress. The cause for their exceptional resistance may be a low content of unsaturated fatty acids or a high level of antioxidants in the cell membran...

This research work aimed to enhance the concentration of some bioactive compounds in culantro (Eryngium foetidum L.) plantlets through gamma irradiation (0.0, 10.0, 20.0 and 40.0 Gy range) treatments. Gamma irradiation at 40.0 Gy significantly stimulated total phenolic, flavonoids, tannin and saponin contents. The effect of irradiation on antioxidant properties of culantro extracts was investig...

In this study, the physicochemical characteristics of pork loin, beef and chicken breast with various wet aging periods were analyzed to derive an appropriate period for each livestock. Pork loin stored at 4°C 0, 1, 2 weeks, was 2, 3, 4 proximate compositions, water holding capacity (WHC), cooking yield, shear force, volatile basic nitrogen (VBN), thiobarbituric acid reactive substances (TBARS)...

BACKGROUND Ischemia and subsequent reperfusion induce lipid peroxidation in the cerebrum of the fetal rat. The present study evaluated the antioxidant activity of endogenous coenzyme Q in protecting against the lipid peroxidation induced in the fetal rat brain by ischemia/reperfusion. METHODS We used wistar rats at day 19 of pregnancy. Fetal ischemia was induced by bilateral occlusion of the ...

Endogenous reproductive hormones and oxidative stress have been independently linked to risk of chronic disease but mostly in postmenopausal women. The interplay between endogenous reproductive hormones and oxidative stress among premenopausal women, however, has yet to be clearly elucidated. The objective of this study was to investigate the association between endogenous reproductive hormones...