Drugs that bind to imidazoline binding proteins have major physiological actions. To date, three subtypes of such proteins, I(1), I(2) and I(3), have been proposed, although characterisations of these binding proteins are lacking. I(2) binding sites are found throughout the brain, particularly dense in the arcuate nucleus of the hypothalamus. Selective I(2) ligands demonstrate antidepressant-li...

PURPOSE/OBJECTIVES To examine associations between diet and persistent cancer-related fatigue (PCRF) in cancer survivors. DESIGN A cross-sectional pilot study. SETTING A university cancer center in Michigan. SAMPLE 40 adult cancer survivors who were recruited from July 2007 to August 2008 and had completed all cancer treatments at least 12 weeks prior to recording their dietary intakes an...

Ultrasound Color Flow Imaging (CFI) has become a valuable tool in a wide rangeof medical applications where information about blood flow can be related to thediagnosis of disease, as for instance in the cardiovascular system. The modalityprovides a map of blood velocity and direction in a twoor three-dimensional regionof interest, where abnormal blood flow patterns can be detect...

OBJECTIVE An examination of whether oxycodone/naloxone prolonged-release tablets (OXN PR) can improve constipation and maintain analgesia, compared with oxycodone prolonged-release tablets (OxyPR) in patients with moderate/severe cancer pain. METHODS Randomized, double-blind, active-controlled, double-dummy, parallel-group study in which 185 patients were randomized to receive up to 120 mg/da...

The Schedule of Fatigue and Anergy/General Physician (SOFA/GP) was developed to screen for prolonged fatigue in the primary care setting. We aimed to evaluate the reliability and validity of the Korean version of the SOFA/GP (SOFA/GP-K), which is adapted from the original English version. We performed translation and back translation, and after conducting a pilot study, we tested the final vers...

OBJECTIVE The aim of this study was to assess safety and efficacy of fixed combination oxycodone prolonged release (PR)/naloxone PR in terms of both analgesia and improving opioid-induced bowel dysfunction (OIBD) and associated symptoms, such as opioid-induced constipation (OIC), in adults with chronic non-cancer pain. STUDY DESIGN These were open-label extension studies in which patients who...

Aims. The combined point spread function (PSF) of the Broadband Filter Imager (BFI) and the Solar Optical Telescope (SOT) onboard the Hinode spacecraft is investigated. Methods. Observations of the Mercury transit from November 2006 and the solar eclipse(s) from 2007 are used to determine the PSFs of SOT for the blue, green, and red continuum channels of the BFI. For each channel large grids of...

Based on the well known biological versatility of the imidazoline nucleus, we prepared the novel derivatives 3a-k inspired by 2-BFI scaffold to assess imidazoline molecules as D(2)-like dopamine receptor ligands. Conservative chemical modifications of the lead structure, such as the introduction of an hydroxy group in the aromatic ring alone or associated with N-benzyl substitution, provided pa...

The aim of this study is the analysis of the beneficial impact of using opioid receptor antagonist associated to opioid analgesic on the quality of life in patients suffering from chronic non-cancer pain. We recruited 60 patients suffering from osteo-articular diseases who were randomized into two groups of treatment. The group A was treated with the association of opioid receptor antagonist an...