tention in a series of 12 patients, according to Sodee, and he discontinued the mercuhydrin injection ( 7 ). McAfee noted that pharmacologists have been unable to block the uptake in the kidneys, despite pre-dosing rats with cold mercurials with doses up to 20 mg of mercury per kilogram, a tremendously toxic dose (8). Although brain scanning with such short-lived isotopes as 99mTcand 197Hg is r...

Pre-eclampsia (PE) is a common but complex condition that can occur in pregnancy. It is estimated to affect 3-8% of pregnancies worldwide. PE development is thought to be multifactorial and to involve the dysregulation of microRNA (miR) expression. However, the precise mechanisms of PE development remain unclear. The present study aimed to illustrate the association between miR‑203 expression a...

Alcoholic liver disease (ALD) is a global liver disease which characterized by liver inflammation, fatty liver, alcoholic hepatitis, or liver cirrhosis. Alcohol abuse is one of the main reasons for liver disease. Alcoholic fatty liver (AFL) disease is the early stage of ALD and associated with the excessive lipids accumulation in hepatocytes as well as oxidative stress. MicroRNA-203 (miR-203) i...

PAGE Part I. Transformation properties of the field equations and conservation laws. . . . . . . . . 203 . Un&ts and notat&on. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 203 2. The variation principle and the energy-momentum tensor; gauge transformation and current vector. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . ...

23 In many mouse models of skin cancer, only a few tumors typically form even though many cells 24 competent for tumorigenesis receive the same oncogenic stimuli. These observations suggest an 25 active selection process for tumor-initiating cells. Here we use quantitative mRNA-and miR-Seq 26 to determine the impact of Hras G12V on the transcriptome of keratinocytes. We discover that 27 microRN...

Fluorinated 2-(4-amino-3-methylphenyl)benzothiazoles possess potent antiproliferative activity against certain cancer cells, similar to the unfluorinated 2-(4-amino-3-methylphenyl)benzothiazole (DF 203, NSC 674495). In "sensitive" cancer cells, DF 203 is metabolized by, can induce expression of, and binds covalently to CYP1A1. Metabolism appears to be essential for its antiproliferative activit...