Shiftwork is often associated with metabolic diseases, and in the past few years, several cytokines have been postulated to contribute to various diseases, including insulin resistance. The aim of this study was to compare the concentrations of adiponectin, tumor necrosis factor-α (TNF-α), and interleukin-6 (IL-6) in samples of young adult men exposed to a fixed (i) night shift (n = 9), working...

OBJECTIVE To analyze the role of autonomic function and other possible factors associated with a blunted fall in nocturnal blood pressure. RESEARCH DESIGN AND METHODS A total of 39 normotensive normnoalbuminuric type 1 diabetic patients were studied. Glomerular filtration rate (51Cr-EDTA technique), extracellular volume (51Cr-EDTA distribution volume), and urinary albumin excretion rate (UAER...

BACKGROUND YH4808, a K+ -competitive acid blocker, is under clinical development for the treatment of acid-related disorders, such as gastroesophageal reflux disease. AIMS To determine the safety, tolerability, pharmacokinetics (PK), and pharmacodynamics (PD) of YH4808, compared to placebo and esomeprazole. METHODS This double-blind, randomised, placebo- and active comparator (esomeprazole)...

Insects inhabiting the temperate zones measure seasonal changes in day or night length to enter the overwintering diapause. Diapause induction occurs after the duration of the night exceeds a critical night length (CNL). Our understanding of the time measurement mechanisms is continuously evolving subsequent to Bünning's proposal that circadian systems play the clock role in photoperiodic time ...

This article presents the results of an experiment which Investigated elementary school children’s explanations of the day/night cycle. First, third, and fifth grade children were asked to explain certain phenomena, such as the disappearance of the sun during the night, the disappearance of stars during the day, the apparent movement of the moon, and the alteratlon of day and night. The results...

human presence and accordingly establishing suitable condition for social interactions are important factors in shaping urban spaces. caring to different aspects of improving environmental qualities especially perception aspect and ease of perception from the environment with legibility improvement is an element that was emphasized from the base of urban design. the role of time, commence of da...

Abstract Introduction Nightshifts represent a substantial proportion of time dedicated to working in the inpatient setting, particularly among ICU staff. Our institution implemented 24/7 in-person attending model more than decade ago. With practice growth and 200 beds across disciplines, there are now at least 8 attendings in-hospital all night. Yet, little is known about staff perceptions desi...

We developed an asymmetric double logistic curve-fitting procedure for circadian analysis that can determine the rate of change in variables during the day-to-night separately from the night-to-day transition for use in animal studies. We now have applied this procedure to 24-h systolic (SAP) and diastolic arterial pressure (DAP) and heart rate ambulatory recordings from 302 patients. In 292 ca...

Direct middle ear (ME) pressure measurements during 24 h and tubal function tests were performed on 11 subjects with the clinical diagnosis patulous Eustachian tube (PET). The pressure was recorded from the ME via a perforation in the tympanic membrane. The method used has previously been reported in a study on subjects with normal ME function and no symptoms of PET: a normal group. Results fro...

OBJECTIVE A disturbed day-night rhythm is associated with metabolic perturbations that can lead to obesity and type 2 diabetes mellitus (T2DM). In skeletal muscle, a reduced oxidative capacity is also associated with the development of T2DM. However, whether oxidative capacity in skeletal muscle displays a day-night rhythm in humans has so far not been investigated. METHODS Lean, healthy subj...