ADS-5102 is a long-acting, extended-release capsule formulation of amantadine HCl administered once daily at bedtime. This study investigated the safety, efficacy, and tolerability of ADS-5102 in Parkinson's disease (PD) patients with levodopa-induced dyskinesia. This was a randomized, double-blind, placebo-controlled, parallel-group study of 83 PD patients with troublesome dyskinesia assigned ...

BACKGROUND Although long-term data are available from biologic studies in North American/European populations with rheumatoid arthritis (RA), long-term findings in Latin American RA populations are limited. OBJECTIVE To examine long-term safety/efficacy of etanercept, methotrexate, and/or other disease-modifying anti-rheumatic drugs (DMARDs) in Latin American patients with moderate-to-severe ...

We have used two actin-binding proteins of the intestinal brush border, TW 260/240 and villin, to examine the effects of filament cross-linking and filament length on myosin-actin interactions. TW 260/240 is a nonerythroid spectrin that is a potent cross-linker of actin filaments. In the presence of this cross-linker we observed a concentration-dependent enhancement of skeletal muscle actomyosi...

We present an overview of BeppoSAX Wide Field Cameras observations of the nine most frequent type I X-ray bursters in the Galactic center region. Six years of observations (from 1996 to 2002) have amounted to 7 Ms of Galactic center observations and the detection of 1823 bursts. The 3 most frequent bursters are GX354−0 (423 bursts), KS 1731−260 (339) and GS 1826−24 (260). These numbers reflect ...

Somatic mutations in the mitochondrial DNA (mtDNA) displacement loop (D-loop) region have been frequently detected in various human cancers. In a previous study, we identified a polyplasmic 260-bp tandem duplication and triplication mutation in the mtDNA D-loop of one gastric cancer. In the present study, we adopted a more sensitive back-to-back polymerase chain reaction method to screen for th...

The present study reports the existence of Purkinje cell-specific phosphoprotein, Mr 260,000 (PCPP-260), a neuronal membrane phosphoprotein, in cerebellar Purkinje cells. PCPP-260, which on sodium dodecyl sulfate-polyacrylamide gel electrophoresis has an apparent molecular mass of 260,000 Da, has been found to be phosphorylated in particulate preparations by endogenous or added exogenous cyclic...

Zeitschrift für ausländisches öffentliches Recht und Völkerrecht / Heidelberg Journal of International Law , Seite 255 - 260