Purpose: A study was made of the effects of some bases and adjuvants on the physical and release properties of metronidazole suppositories with a view to providing more information for the optimization of the rectal formulation of metronidazole. Method: Suppositories (1g) containing 200mg of metronidazole each were prepared in witepsol (H15 and E75) and polyethylene glycol (PEG 2850 and 4650) b...

MATERIALS AND METHODS Vinblastine was incubated in 0.2 M glycine buffer (pH 7.4 or 8.8) containing bovine serum albumin (1%) at 37°Cfor 72 h. The reaction mixture was extracted with CH2CI2, and the extract gave 6 major peaks (A, B, C, D, E, and F) with retention times of 5.0, 7.5, 11.0, 13.0, 23.0, and 30.0 min, respectively, in a high-performance liquid chromatography system (/¿Bondapak CÃ-a...

Epinephrine (adrenaline) is the treatment of choice for anaphylaxis. While other medications, including H1-antihistamines, H2-antihistamines, corticosteroids, and inhaled beta-2 agonists are often used to treat anaphylaxis in the emergency setting, none of these medications has been shown to reverse anaphylaxis. Fatal anaphylaxis is related to the delayed use of epinephrine. In community settin...

Objective: To compare the frequency of maternal and fetal outcome in pregnant women with BMI ≤ 25 kg/m2 > at Tertiary Care Hospital, Karachi. Study Design: Descriptive study. Place Duration: was conducted Department Gynaecology Obstetrics, Aga Khan University Hospital. Duration six months after approval from 7th November, 2019 till May 2020. Subjects Methods: Data prospectively collected pat...