BACKGROUND Dihydropyrimidinase Related Proteins (DRPs) have known homologous to the Collapsing Response Mediator Proteins (CRMPs). The DRP gene family has comprised four members, DRP 1, 2, 3, and 4, all out of which have considered to be involved in axonal outgrowth and path-finding. METHODS The protein has extracted from tumor, normal brain tissues, and then the protein purity has evaluated ...

Jensen TE, Rose AJ, Hellsten Y, Wojtaszewski JF, Richter EA. Caffeine-induced Ca release increases AMPK-dependent glucose uptake in rodent soleus muscle. Am J Physiol Endocrinol Metab 293: E286–E292, 2007. First published April 3, 2007; doi:10.1152/ajpendo.00693.2006.—Previous studies have proposed that caffeine-induced activation of glucose transport in skeletal muscle is independent of AMP-ac...

Previous data have strongly implicated hindbrain catecholamine/neuropeptide Y (NPY) coexpressing neurons as key mediators of the glucoprivic feeding response. Catecholamine/NPY cell bodies are concentrated in the A1 and caudal C1 cell cluster (A1/C1) in the ventrolateral medulla, a region highly sensitive to glucoprivic challenge. To further investigate the importance of this catecholamine subp...

1 D-pinitol (3-O-methyl-chiroinositol), an active principle of the traditional antidiabetic plant Bougainvillea spectabilis, is claimed to exert insulin-like e€ects. This study investigates the e€ect of D-pinitol on glucose homeostasis in animal models of diabetes, and on glucose transport by cultured muscle cells. 2 Plasma glucose concentrations were measured in normal, obese-diabetic (ob/ob) ...

Previous studies have proposed that caffeine-induced activation of glucose transport in skeletal muscle is independent of AMP-activated protein kinase (AMPK) because alpha-AMPK Thr172 phosphorylation was not increased by caffeine. However, our previous studies, as well as the present, show that AMPK phosphorylation measured in whole muscle lysate is not a good indicator of AMPK activation in ro...

The dissociative anesthetic ketamine elicits symptoms of schizophrenia at subanesthetic doses by blocking N-methyl-Daspartate receptors (NMDARs). This property led to a variety of studies resulting in the now well-supported theory that hypofunction of NMDARs is responsible for many of the symptoms of schizophrenia. However, the roles played by specific NMDAR subunits in different symptom compon...

The dissociative anesthetic ketamine elicits symptoms of schizophrenia at subanesthetic doses by blocking N-methyl-d-aspartate receptors (NMDARs). This property led to a variety of studies resulting in the now well-supported theory that hypofunction of NMDARs is responsible for many of the symptoms of schizophrenia. However, the roles played by specific NMDAR subunits in different symptom compo...

Abstract Lowered glucose availability, sensed by the hindbrain, has been suggested to enhance gluconeogenesis and food intake as well suppress reproductive function. In fact, our previous histological in vitro studies suggest that hindbrain ependymal cells function a sensor. The present study aimed clarify sensor-hypothalamic neural pathway activated response glucoprivation mediate counterregul...

We present a first principles description of the interaction of two ground-state scandium atoms. Scandium has a Dg ground state. Thirty molecular states correlate to the lowest dissociation limit of the dimer. In the short range, potential energy curves are calculated using second-order n-electron valence state perturbation theory. The first-order long-range interaction is calculated at the com...