We report a patient with tetralogy of Fallot who developed spontaneous bilateral perirenal hematoma at the age of 35. Polycythemia was seen from the age of 3 in this patient. Prolonged clotting time and partial thromboplastin time were observed on various occasions before he developed perirenal hematoma. Blood letting was done periodically according to the value of hemoglobin level and packed c...

Heparin has been conventionally used as an anticoagulant for medical and surgical indications. Because factor Xa is an essential component of the prothrombinase complex and leads to the generation of thrombin, its inhibition has become a focus of newer antithrombotic drug development. The in vitro anticoagulant profile of DX-9065a, a synthetic direct factor Xa inhibitor, was studied using activ...

BACKGROUND Therapeutic plasma exchange (TPE)-based protocols immediately before cadaveric donor kidney transplantation have been extensively used in highly sensitized recipients. Plasma is generally preferred over human albumin as replacement fluid to avoid depletion of coagulation factors and perioperative bleeding. The aim of this study was to estimate bleeding risk after TPE replaced with al...

Toona microcarpa Harms is a tonic, antiperiodic, antirheumatic, and antithrombotic agent in China and India and an astringent and tonic for treating diarrhea, dysentery, and other intestinal infections in Indonesia. In this study, we prepared ethyl-acetate extract from the air-dried leaves of Toona microcarpa Harms and investigated the anticoagulant activities in vitro by performing activated p...

Increasing clinical experience has gradually diminished the number of laboratory tests required for monitoring thrombolytic therapy. Still wider and wider use of plasminogen activators, often without a specialized laboratory basis, makes it imperative that some easily performed and reproducible tests should be at our disposal. Such conditions seem to be fulfilled by a simple assay of plasma clo...

The differential diagnosis of a long APTT with a normal prothrombin time can be due to either a clotting factor deficiency or the presence of an inhibitor, which can be distinguished by using a plasma-mixing study. The various clotting factor deficiency states are reviewed. Clinical bleeding following cardiac bypass surgery due to acquired factor V and thrombin antibodies is also reviewed.

Background—Unfractionated heparin has been the primary anticoagulant therapy for percutaneous coronary intervention for .20 years. Despite the availability of rapid “point of care” testing, little clinical data defining the optimal level of anticoagulation are available. Furthermore, recent reports have advocated the use of low-dose heparin regimens in the absence of large-scale, well-conducted...

The effect of hypothermia on heparin anticoagulation was studied using (siliceous earth) activated clotting time (ACT) measured by the modified Hattersley technique and anti-factor Xa assay measured by the modified Teien technique during cardiopulmonary bypass (CPB). Seventeen adult patients with normal blood coagulation function undergoing their first time coronary artery bypass grafting surge...

Percutaneous Coronary Intervention To the Editor: We read with interest the article by Chew et al1 in the February 20, 2001, issue of Circulation, but we were disappointed that such eminent investigators could confuse associations arising from heterogeneous pooled data with hard evidence on which scientific conclusions can be drawn. In their Conclusions, they state that their meta-analysis “. ....