Single-nucleotide polymorphisms within major histocompatibility class II (MHC II) genes have been associated with an increased risk of drug-induced liver injury. However, it has never been addressed whether the MHC II pathway plays an important role in the development of nonalcoholic fatty liver disease, the most common form of liver disease. We used a mouse model that has a complete knockdown ...

AIM Liver fibrosis is a reversible wound-healing response that occurs following liver injury. In this study, we aimed to investigate the possible protective effects of L-carnitine, N-acetylcysteine and genistein in liver fibrosis induced by carbon tetrachloride (CCl4). In addition, the effects of these agents were compared in the same study. METHODS In this study, rats were randomly allocated...

To explore hepatoprotective role and underlying mechanisms of Trillium tschonoskii Maxim (TTM), 36 rats were randomly divided into control, CCl4-induced liver injury model, and biphenyl dimethyl dicarboxylate (DDB) and low-, moderate-, and high-dose TTM treatment groups. After CCl4-induced model establishment, the rats from DDB and TTM groups were administrated with DDB at 0.2 g/kg per day and ...

Prostate cancer (PCa) is the second leading cause of cancer-related deaths in men in the United States and is the most commonly diagnosed non-cutaneous cancer. CCL4 is a secreted chemokine that is over expressed in patients that show PCa recurrence after prostatectomy. Currently, no reported evidence shows the biological role of CCL4 in PCa progression. We studied the role of CCL4 in PCa progre...

BACKGROUND Sonchus asper (SAME) is used as a folk medicine in hepatic disorders. In this study, the hepatoprotective effects of the methanol extract of SAME was evaluated against carbon tetrachloride (CCl4)-induced liver injuries in rats. METHODS To evaluate the hepatoprotective effects of SAME, 36 male Sprague-Dawley rats were equally divided into 6 groups. Rats of Group I (control) were giv...

Different parts of Icacina trichanta has been used for ethnomedicinal purposes; this study was undertaken to investigate the effects plant on CCl4- induced renal damage. Phytochemical analyses were carried out powdered sample using standard procedures. Absolute organ weight, Urea, creatinine, total protein, superoxide dismutase, catalase and malondialdehyde levels determined. Consequently, thir...

The role of Nigella Sativa (NS) was investigated in the prevention of carbon tetrachloride (CCl4) induced liver fibrosis. Twenty seven adult wistar-albino rats were allocated into three groups (control, CCl4-induced hepatotoxicity and hepatotoxicity and NS-treated) and after the treatment, rats were sacrified, blood samples were collected for determination of plasma aminotransferases, malondial...

BACKGROUND AND AIM The pharmacokinetics of acemetacin, a non-steroidal anti-inflammatory drug which is biotransformed to indomethacin by hepatic first-pass effect, was examined during the necrotic and regeneration phases resulting from acute hepatitis induced by carbon tetrachloride (CCl4). MATERIAL AND METHODS Acute hepatitis was induced by oral CCl4 administration to male Wistar rats. On da...

AIM To assess the effects of dihydromyricetin (DHM) as a hepatoprotective candidate in reducing hepatic injury and accelerating hepatocyte proliferation after carbon tetrachloride (CCl4) treatment. METHODS C57 BL/6 mice were used in this study. Mice were orally administered with DHM (150 mg/kg) for 4 d after CCl4 treatment. Serum and liver tissue samples were collected on days 1, 2, 3, 5 and ...

The effects of aqueous leaves extract of the Gardenia ternifolia plant (ALEGTP) was investigated against carbon tetrachloride (CCl4) induced hepatotoxicity in rats. Thirty albino rats were used for the experiment and grouped into six (n=5); group 1 and 2 were normal and control respectively. Group 3 was pretreated with silymarin while group 4, 5 and 6 were pretreated with 100, 200 and 400 mg/kg...