Cell contractility and migration by integrins depends on precise regulation of protein tyrosine kinase and Rho-family GTPase activities in specific spatiotemporal patterns. Here we show that protein tyrosine phosphatase PTP1B cooperates with β3 integrin to activate the Src/FAK signalling pathway which represses RhoAmyosin-dependent contractility. Using PTP1B null (KO) cells and PTP1B reconstitu...

The notion of distance is fundamental to many aspects of computational geometry. A classic approach to characterize the distance properties of planar (and highdimensional) point sets that has been studied since the early 1980s are proximity graphs (Section 32.1). Proximity graphs are geometric graphs in which two vertices p, q are connected by an edge (p, q) if and only if a certain exclusion r...

Certain naturally occurring spaces have isomorphic v 1-periodic homotopy groups. To each is associated a mapping telescope whose ordinary homotopy groups equal the v 1-periodic homotopy groups of the space. It is proved that the mapping telescopes of the spaces are homotopy equivalent .

Acetaminophen is a leading cause of acute liver failure (ALF). Genetic differences might predispose some individuals to develop ALF. In this exploratory study, we evaluated genotype frequency differences among patients enrolled by the ALF Study Group who had developed ALF either intentionally from a singletime-point overdose of acetaminophen (n = 78), unintentionally after chronic high doses of...

Acetaminophen is a leading cause of acute liver failure (ALF). Genetic differences might predispose some individuals to develop ALF. In this exploratory study, we evaluated genotype frequency differences among patients enrolled by the ALF Study Group who had developed ALF either intentionally from a singletime-point overdose of acetaminophen (n = 78), unintentionally after chronic high doses of...

KChIPs coassemble with pore-forming Kv4 a subunits to form a native complex in the brain and heart and regulate the expression and gating properties of Kv4 K1 channels, but the mechanisms underlying these processes are unknown. Here we report a co-crystal structure of the complex of human Kv4.3 N-terminus and KChIP1 at a 3.2-Å resolution. The structure reveals a unique clamping action of the co...

ITE JOURNAL / JANUARY 2001 THE NATIONAL DIALOGUE ON Transportation Operations has identified the need for cultural transitions within transportation organizations from traditional project-driven orientations to approaches focused on continuous systems performance and customer service.1 Institutional change, facilitating interjurisdictional cooperation to provide seamless transportation services...