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Introduction In recent years, there have been many developments in the field of fast preclinical imaging based on EPI sequences whether to study brain function with BOLD-fMRI [1], brain anatomy with DWI [2] or image the accumulation of contrast media in tissue with DCE-MRI [3]. Echo Volumar Imaging (EVI) is a 3D extension of EPI that possess the same advantages (elevated signal-to-noise ratio, ...
Background: No term exists to date describing the phenomenon of pink-to-red discoloration after an inflammatory acne lesion. Objectives: To introduce new terminology into the dermatology literature to describe erythema often seen after inflammatory acne vulgaris and to present a treatment option for this type of erythema. Methods: New terminology describing erythema after inflammatory acne is a...
Introduction: The area at risk (AAR) of infarction is the hypoperfused myocardial bed during coronary occlusion. The edematous AAR can be delineated in-vivo by T2 MRI and can be used in conjunction with delayed contrast enhancement to calculate myocardial salvage. T1 MRI has been recently used to image the edema associated with acute myocardial infarction. Objectives: We hypothesized that, due ...
Indiana University has designed and finished construction of the Midwest Proton Radiotherapy Institute (MPRI) [1] consisting of one treatment room with two fixed horizontal beam lines and two treatment rooms with isocentric gantries. The first treatment room has been operating since February 2004, while the first Gantry treatment room has been in use treating patients since April 2007. The prot...
BACKGROUND Menopausal hormone therapy (MHT) reportedly increases the risk of cognitive decline in women over age 65 y. It is unknown whether similar risks exist for recently postmenopausal women, and whether MHT affects mood in younger women. The ancillary Cognitive and Affective Study (KEEPS-Cog) of the Kronos Early Estrogen Prevention Study (KEEPS) examined the effects of up to 4 y of MHT on ...
Background: Cell therapies are a very active field of research. For proper identification of the optimal application mode ensuring efficient deposition and sufficient continuance of the cells at the target position, a detailed understanding of the cell trafficking and homing is required. Iron-labelled cells have been proven to enable in-vivo monitoring of the trafficking and homing of cells aft...
Two dimensional (2D) spectroscopy is very important for unambiguous assignment of overlapping metabolite signals. Although spectral simplification can be obtained through 1D spectral-editing techniques by filtering out some of the signals, the 2D spectra retain all the spectral information and could be more efficient in obtaining the complete metabolic profile. To date, 2D COSY (COrrelation Spe...
MRI myocardial tagging offers a tremendous opportunity to quantitatively, serially and noninvasively examine the intramyocardial motion and deformation [l-51. The ideal presaturation or tagging stripe should be of rectangular intensity profile and controllable width with respect to the distance between adjacent stripes. Here we propose a sinc modulated RF pulse train that offers sharper-edged t...
Discussing the non-adherence to diet or medication with chronic haemodialysis patients can be an utterly frustrating experience, especially if one does this thrice a week. It is also a reflection of the fact that for more than half a century, nephrologists have been focusing on cardiovascular morbidity and mortality in chronic kidney disease (CKD) patients. Over the last decade, however, burgeo...
Introduction: Whole heart coronary MRA is typically performed with navigator gating because of the large data needed to achieve an isotropic spatial resolution on the order of 1-2 mm with extensive anatomic coverage (10-16 cm). Previous studies have shown that whole heart coronary MRA can be performed with either a single [1] or double [2,3] breath-hold (BH) approach using highly-accelerated pa...
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