Background: Second-generation oral antihistamines (AH) and intranasal corticosteroids (ICS) are the most widely used drugs for allergic rhinitis (AR). Objective: To obtain information on the preferences for and applications of these drugs under conditions of routine clinical practice. Methods: We performed a multicenter multidisciplinary observational study. Participating physicians completed a...

In this paper we propose a derivative-free iterative method for the approximate solution of a nonlinear inverse problem Fx = y. In this method the iterations are defined as Gxk+1 = Gxk +(Sy−SFxk), where G is an easily invertible operator and S is an operator from a data space to a solution space. We give general suggestions for the choice of operators G and S and show a practically relevant exa...

The article presents results of a special project aimed at re-examining the grave associated with Globular Amphora culture in Sandomierz Upland. main purpose was to obtain data establish absolute chronology graves. In total, reported produced 25 age determinations samples from 17 sepulchral features. Some are second attempts date same sample an effort make calibrated BC ranges more accurate. se...

Estrogen replacement therapy has been associated with reduction of cardiovascular events in postmenopausal women, though the mechanism for this benefit remains unclear. Here we show that at physiological concentrations estrogen activates the anandamide membrane transporter of human endothelial cells and leads to rapid elevation of calcium (apparent within 5 minutes) and release of nitric oxide ...

We review the main results of the seminal paper of Widom [2] on asymptotics of or-thogonal and Chebyshev polynomials associated with a set E (i.e., the monic polynomialsof degree at most n that minimize the sup-norm‖Tn‖E), where E is a system of Jordanregions and arcs. Thiran and Detaille [1], considered the Chebyshev polynomials Tn on acircular arc Aα and managed to fin...

We develop a dual representation of the technology of international fragmentation for an industry using 2 factors in a continuum of stages. We then derive a generalised factor price frontier which incorporates an endogenous adjustment of the margin fragmentation. Using this frontier in a 2×2 general equilibrium model, we investigate the role of outsourcing in the adjustment to a decline in the ...

The di-electron widths of ψ(4040), ψ(4160), and ψ(4415), and their ratios are shown to be in good agreement with experiment, if in all cases the S − D mixing with a large mixing angle θ ≈ 34 is taken. Arguments are presented why continuum states give small contributions to the wave functions at the origin. We find that the Y (4360) resonance, considered as a pure 3 D1 state, would have very sma...

Epigenetic regulation allows heritablymodulating gene expression profiles without modifying the primary sequence of gDNA. Under physiologic conditions, epigenetic patterns determine tissue-specific gene expression landscapes, gene imprinting, inactivation of chromosome X, and preservation of genomic stability. The most characterized mediators of epigenetic inheritance are gDNA methylation and h...

AIMS More than 90% of cases of renovascular disease (RVD) are caused by atherosclerosis; thus patients with this condition are at high risk for vascular events. We examined the association of statins with prognosis in patients with RVD. METHODS AND RESULTS We performed a population-based cohort study in 4040 patients with RVD older than 65 years using province-wide health data in Ontario, Can...

This study was designed to evaluate the efficacy of the HealthWise South Africa HIV and substance abuse prevention program at impacting adolescents' polydrug use and sexual risk behaviors. HealthWise is a school-based intervention designed to promote social-emotional skills, increase knowledge and refusal skills relevant to substance use and sexual behaviors, and encourage healthy free time act...