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M. Livingstone, P. Sziber, W. Quinn, Cell 37, 205 (1984); P. Drain, E. Folkers, W. Quinn, Neuron 6, 71 (1991); Z. L. Wu et al., Proc. Natl. Acad. Sci. U.S.A. 92, 220 (1995); W. Li, T. Tully, D. Kalderon, Learn. Mem. 2, 320 (1996). 3. E. Skoulakis, D. Kalderon, R. Davis, Neuron 11, 197 (1993). 4. A. Nighorn, M. Healy, R. Davis, ibid. 6, 455 (1991); P. Han, L. Levin, R. Reed, R. Davis, ibid. 9, 6...
HomePlant DiseaseVol. 105, No. 9First Report of Fusarium equiseti Causing Wilt Cajanus scarabaeoides, a Wild Relative Pigeonpea, in India PreviousNext DISEASE NOTE OPENOpen Access licenseFirst IndiaRaj K. Mishra, Monika Abhishek Bohra, Satheesh Naik SJ, P. R. Saabale, Krishna Kumar, Prakash G. Patil, D. Srivastava, and N. SinghRaj Mishra†Corresponding author: Raj Mishra; E-mail Address: rkmishr...
Background While immune checkpoint blockade therapy has improved progression-free survival in patients suffering from cancer over other treatments, 1–4 these typically elicit durable responses only minority of patients, part because the highly immunosuppressive tumor microenvironment (TME). 5 6 Rational combinations with inflammatory cytokines can relieve some immunosuppression, 7 8 but systemi...
Carbocyclic nucleosides have been the focus of much recent attention in the development of new antitumor and antiviral therapeutic agents.1 The search for antiviral agents, particularly for the treatment of human immunodeficiency virus (HIV) and hepatitis B virus (HBV), resulted in the discovery of carbovir (1), which has been shown to possess significant in vitro activity as an inhibitor of HI...
Lusková V. , M. Svoboda, J . Koláfiová: The Effect of Diazinon on Blood Plasma Biochemistry in Carp (Cyprinus carpio L.). Acta Vet. Brno 2002, 71: 117-123. The aim of this study was to evaluate the effect of diazinon [0,0-diethyl-0-(2-isopropyl-6methylpyrimidin-4yl) phosphorothioate] on common carp (Cyprinus carpio L.). The effect was assessed by comparing the biochemical blood plasma profiles ...
Distributed Virtual Machine (DVM) Heterogeneous computational resources Services (plug-ins) Baseline Figure 1: Overview of the Harness system. 2.1 Fundamental Abstractions and System Architecture The fundamental abstraction in the Harness metacomputing framework is the Distributed Virtual Machine (DVM) (see gure 1, level 1). A DVM is associated with a symbolic name that is unique within a Harne...
•Northern peatlands remain a CO2 sink of ?0.1 Pg C year?1 until 2300 under RCP2.6•Northern become source ?0.2 by RCP8.5•CH4 emissions from northern will increase 5-fold RCP8.5•Modeling peatland resilience, vegetation, and peat quality changes should be improved Intact remove carbon dioxide (CO2) the atmosphere through photosynthesis store in soils waterlogged conditions, while emitting methane ...
•Heterocellular spheroids of the NVU are biofabricated by a simple method•Heterocellular express key structural and functional proteins BBB•RNA-Seq analysis confirmed high expression endothelial cell-specific genes•Nanoparticles enter spheroid, likely activated microglia astrocytes Nanoneuromedicine investigates nanotechnology to target brain treat neurological diseases. In this work, we hetero...
Immunotherapy is a potential way to save the lives of patients with bladder cancer, but it only benefits approximately 20% them. A total 4,028 cancer were collected for this study. Unsupervised non-negative matrix factorization and nearest template prediction algorithms employed classification. We identified immune non-immune classes from The Cancer Genome Atlas Bladder Urothelial Carcinoma (TC...
Common wheat (Triticum aestivum L.) is one of the most important cereal crops. Wheat powdery mildew caused by Blumeria graminis f. sp. tritici (Bgt) is a continuing threat to wheat production. The Pm21 gene, originating from Dasypyrum villosum, confers high resistance to all known Bgt races and has been widely applied in wheat breeding in China. In this research, we identify Pm21 as a typical c...
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