Employing newly synthesized di-substituted tri-phenyl amine (HMP-9) and carbazole (HMP-11) dyes (with limited acidic carboxyl anchor groups), a power conversion efficiency as high as 7.03% in ZnO nanocrystallite (NC)-based dye-sensitized solar cells (DSSCs) is achieved. The specific molecular designs of HMP-09 and HMP-11 consisting of with and without hexyloxy spacer groups, and added tri-pheny...

3(5)-Phenyl-1H-pyrazoles are employed in this study to develop highly efficient organic crystalline solids with deep-blue ESIPT fluorescence as well as provide novel experimental insight into the mechanism of ESIPT fluorescence and generate an intriguing fluorescence "ON/OFF" switching.

The solvent-free reaction between 5-amino-1H-pyrazoles and -triketones (2-acetyldimedone and 2acetylindandione) leads to the formation of new fused pyrazolo[1,5-a]pyrimidines in good yields. A possible mechanistic route is postulated on the basis of the isolation of the cyclization intermediate. The structures and regiospecificity of the reaction were determined on the basis of nmr measurements...

An efficient and regioselective procedure for the synthesis of di-, tri- and fully-substituted pyrazolidine-3,5-diones on a solid-phase format is described. Microwave irradiation provided significant rate enhancement in this protocol. To demonstrate the versatility of this chemistry, a representative set of 25 compounds was prepared.

Mimicry of two faces of an α-helix might yield more potent and more selective inhibitors of aberrant, helix-mediated protein-protein interactions (PPI). Herein, we demonstrate that a 2,6,9-tri-substituted purine is capable of disrupting the Mcl-1-Bak-BH3 PPI through effective mimicry of key residues on opposing faces of the Bak-BH3 α-helix.

The olefin cross-metathesis (CM) reaction is used extensively in organic chemistry and represents a powerful method for the selective synthesis of differentially substituted alkene products. Surprisingly, efforts to integrate this remarkable process into strategies for aromatic and heteroaromatic construction have not been reported. Such structures represent key elements of the majority of smal...