OBJECTIVE The objective of this study was to evaluate the frequencies of human platelet antigens in oncohematological patients with thrombocytopenia and to analyze the probability of their incompatibility with platelet transfusions. METHODS Platelet antigen genotyping was performed by sequence-specific primer polymerase chain reaction (SSP-PCR) for the HPA-1a, HPA-1b, HPA-2a, HPA-2b, HPA-3a, ...

introduction thunderstorms pose a significant threat to modern societies and their assets. despite their local-scale characteristics, severe thunderstorms and associated extreme events like heavy rainfall, hail, gusts, or tornadoes can cause considerable damage to agriculture, buildings, or infrastructure, and facilities. thunderstorms are highly localized and largely stationary weather systems...

A possibly new teleconnection has been discovered off the east coast of Australia in the region around Tasman sea and Southern Ocean. Found in pressure anomalies using a novel graph based approach called shared reciprocal nearest neighbors, this dipole appears in reanalysis datasets such as NCEP, JRA, ERA and MERRA. The HadSLP2 observation data shows the new dipole, despite of limited observati...

Glucocorticoid negative feedback regulation of the hypothalamic-pituitary-adrenal (HPA) axis is mediated by corticosteroid receptors. It is widely thought that during stress, glucocorticoid receptors (GR) are essential for this negative feedback. In contrast, mineralocorticoid receptors (MR) are associated with HPA axis regulation in basal, nonstress conditions. Notions about the relative roles...

Abstract A k- means clustering method is applied to daily ERA5 500-hPa heights, sea level pressure, and 850-hPa winds, 1979–2008, identify characteristic weather types (WTs) for September–November the northeast United States. The resulting WTs are analyzed in terms of structure, frequency occurrence, typical progressions, precipitation temperature characteristics, relation teleconnections. used...

Abstract The Gamma-ray Observation of Winter Thunderclouds collaboration has detected 70 gamma-ray glows, a high-energy phenomenon associated with thunderstorms, from October 2016 to March 2020 in Kanazawa and Komatsu, Ishikawa Prefecture, central part Japan facing the Sea Japan. Based on surface 500 hPa analyses, numerical prediction models, satellite observations, we classify their synoptic m...

Fetal and neonatal alloimmune thrombocytopenia (FNAIT) is a disease that may cause severe bleeding complications with risk of perinatal death or lifelong disability. The main cause of FNAIT is maternal antibodies against human platelet antigen (HPA)-1a. Both fetomaternal bleeding and transplacental trafficking of fetal cells during pregnancy could be the cause of alloimmunization. Persistence o...

A novel application of a technique developed from chaos theory is used in describing seasonal to interannual climate predictability over the Northern Hemisphere (NH). The technique is based on an empirical forecast scheme-local approximation in a reconstructed phase space-for time-series data. Data are monthly 500 hPa heights on a latitude-longitude grid covering the NH from 20°N to the equator...

Polymorphism of human platelet antigens (HPAs) leads to alloimmunizations and immune-mediated platelet disorders including fetal-neonatal alloimmune thrombocytopenia (FNAIT), posttransfusion purpura (PTP), and platelet transfusion refractoriness (PTR). HPA typing and knowledge of antigen frequency in a population are important in particular for the provision of HPA-matched blood components for ...