Spi-B and PU.1 are hematopoietic-specific transcription factors that constitute a subfamily of the Ets family of DNA-binding proteins. Here we show that contrary to previous reports, PU.1 and Spi-B have very different expression patterns. PU.1 is expressed at high levels in B cells, mast cells, megakaryocytes, macrophages, neutrophils, and immature erythroid cells and at lower levels in mature ...

The emergence of a service economy facilitates proliferation of software service companies (SSCs), small firms offering various software services such as software maintenance, testing, and customization. Given the unique characteristics of SSCs (i.e., smallscale projects, limited resources, strong customer dependency, etc.), software process improvement (SPI) in SSCs faces additional challenges...

We introduce the spi calculus, an extension of the pi calculus designed for describing and analyzing cryptographic protocols. We show how to use the spi calculus, particularly for studying authentication protocols. The pi calculus (without extension) suffices for some abstract protocols; the spi calculus enables us to consider cryptographic issues in more detail. We represent protocols as proce...

Software process improvement (SPI) has emerged as a critical area for organizations involved in software development. There is now considerable evidence that SPI can provide substantial gains in quality, productivity, and cycle time. Currently, most organizations that embark upon a SPI program tend to use a framework like the Capability Maturity Model for their process improvement. In this arti...

Invasion of the intestinal epithelium is a critical step in Salmonella enterica infection and requires functions encoded in the gene cluster known as Salmonella Pathogenicity Island 1 (SPI-1). Expression of SPI-1 genes is repressed by L-arabinose, and not by other pentoses. Transport of L-arabinose is necessary to repress SPI-1; however, repression is independent of L-arabinose metabolism and o...

As seen in literature, about 70% of the improvement initiatives fail, and a significant number do not even get started. This paper analyses the problem of failing initiatives on Software Process Improvement (SPI), and proposes good practices supported by motivational tools that can help minimizing failures. It elaborates on the hypothesis that human factors are poorly addressed by deployers, es...

Intracellular trafficking of the precursor of Spitz (Spi), the major Drosophila EGF receptor (EGFR) ligand, is facilitated by the chaperone Star, a type II transmembrane protein. This study identifies a novel mechanism for modulating the activity of Star, thereby influencing the levels of active Spi ligand produced. We demonstrate that Star can efficiently traffic Spi even when present at sub-s...

Salmonella Typhimurium has a broad arsenal of genes that are tightly regulated and coordinated to facilitate adaptation to the various host environments it colonizes. The genome of Salmonella Typhimurium has undergone multiple gene acquisition events and has accrued changes in non-coding DNA that have undergone selection by regulatory evolution. Together, at least 17 horizontally acquired patho...

BACKGROUND The surgical pleth index (SPI) is proposed for titration of analgesic drugs during general anesthesia. Several reports have investigated the effect of SPI on the consumption of opioids including remifentanil, fentanyl, and sufentanil during anesthesia, but there are no reports about oxycodone. We aimed to investigate intravenous oxycodone consumption between SPI-guided analgesia and ...

This paper aims to simplify FPGA designs that incorporate Embedded Software Systems using a soft core Processor. It describes a simple solution to reduce the need of multiple non-volatile memory devices by using one SPI (Serial Peripheral Interface) Flash PROM for FPGA configuration data, software code (Processor applications), and miscellaneous user data. We have thus developed a design based ...