CA (carbonic anhydrase) catalyses the reversible hydration of carbon dioxide into bicarbonate, and at least 14 isoforms have been identified in vertebrates. The role of CA type II in maintaining the fluid and pH balance has made it an attractive drug target for the treatment of glaucoma and cancer. 667-coumate is a potent inhibitor of the novel oncology target steroid sulphatase and is currentl...

Virgin female mice, CF#1 strain, were continuously irradiated with 60Co gamma rays at a dose-rate of 6 R/day from conception to natural death. A marked life shortening was found for the irradiated group. The mean life span of irradiated group was 384•}25 days (the mean accu mulated dose being 2307.7 R), while that of the non-irradiated control group was 642•}12 days. To demonstrate the somatic ...

Abstract not available Bangladesh Journal of Medical Science Vol. 21 No. 04 October’22 Page : 667-675

Abstract: Peganum harmala L. (Zygophylaceae) has been used in a variety of practical applications in medical science. Our objective in the current study was to determine the effects of the seed extract on Herpes simplex virus type 1 (HSV-1) replication in Vero cells. Different concentrations (100, 500, 571, 667, 800 and 1000 µg/ml) of the extract were examined. Experiments were carried ...

The distribution and abundance of lizards relative to habitat structure were studied at Pukerua Bay, Wellington between December 1982 and March 1988 in order to identify options for management of the habitat of the five species of lizards present. One species, Whitaker’s skink (Cyclodina whitakeri), is a threatened species with only one known mainland population. Pitfall traps were set for 23 6...

Victoria Pure Blue BO is a dye that bears some therapeutic activity and can be retrieved in effluent or may used aquaculture as prohibited drug. In this study, the metabolism tissue distribution during uptake depuration of VPBO were investigated order to propose residue marker illegal treatment fish. The was administered rainbow trout (oncorhynchus mykiss) for one day by water bath at dose 0.1 ...

A functional allele of the mouse catechol-O-methyltransferase (Comt) gene is defined by the insertion of a B2 short interspersed repeat element in its 3'-untranslated region (UTR). This allele has been associated with a number of phenotypes, such as pain and anxiety. In comparison with mice carrying the ancestral allele (Comt+), Comt B2i mice show higher Comt mRNA and enzymatic activity levels....

Reseña de Historia Augusta, edición y traducción Javier Velaza, Madrid, Cátedra, Letras Universales, 2022, 567 páginas, ISBN 978-84-376-447-9