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2-Acetyl-5,6,7,8-tetrahydronaphthalene (1) was allowed to react with different aromatic aldehydes to produce the cyanopyridones 2a and 2b, which were treated with phosphorous pentasulfide to afford the corresponding thioxopyridine derivatives 3a and 3b, respectively. The reaction of 3a and 3b with ethyl bromoacetate afforded the ester derivatives 4a and 4b, while their condensation with hydrazi...

Mark C. Chappell1* and Ebaa M. Al Zayadneh2 1Department of Surgery/Hypertension and Vascular Research, Cardiovascular Sciences Center, Wake Forest School of Medicine Winston-Salem, NC, USA 2Department of Physiology and Biochemistry, University of Jordan, Amman, Jordon *Corresponding author: Mark C. Chappell, Department of Surgery/Hypertension and Vascular Research, Cardiovascular Sciences Cente...

inhibitors of soluble epoxide hydrolase (seh) represent one of the novel pharmaceutical approaches for treating hypertension, vascular inflammation, pain and other cardiovascular related diseases. most of the potent seh inhibitors reported in literature often suffer from poor solubility and bioavailability. toward improving pharmacokinetic profile beside favorable potency, two series of 4-benza...

Setiap orang memiliki panggilan unik dari Tuhan, termasuk hidup menikah atau tidak. Ada asumsi bahwa selibat adalah yang tidak lazim normal. Di sisi lain, dijadikan sebuah persyaratan mutlak bagi seorang imam tahbisan di dalam gereja Katolik. Alkitab menjunjung tinggi pernikahan, tetapi juga mengajarkan tentang karunia (1 Kor. 7:7). Artikel ini bertujuan untuk menjelaskan sebagai Tuhan berdasar...