16 The Journal of Clinical Investigation http://www.jci.org Volume 115 Number 1 January 2005 1. Persson, C.G. 1985. On the medical history of xanthines and other remedies for asthma: a tribute to HH Salter. Thorax. 40:881–886. 2. Barnes, P.J. 2003. Theophylline: new perspectives for an old drug. Am. J. Respir. Crit. Care Med. 167:813–818. 3. Fredholm, B.B., and Persson, C.G. 1982. Xanthine deri...

Although estrogens exert a pronounced protective effect on multiple sclerosis and its animal model, experimental autoimmune encephalomyelitis (EAE), their therapeutic application has been limited by undesirable side effects thought to be mediated primarily through estradiol binding to intracellular estrogen receptor alpha. In this study, we found that signaling through the putative membrane est...

objective: estrogen receptor alpha protein status is determined by routine immunohistochemistry analysis in all malignant breast tumors. this assay has its limitations. rna based techniques are potential complements for immunohistochemistry but it must be noticed that gene silencing may occur at different levels from rna to protein. the aim of this study was the comparison of the results from t...

background: multiple sclerosis is a common and chronic neurologic disorder. this disorder imposes physical, economic, and psychosocial burden on individuals, their families and society. this study aims to analyze the costs of multiple sclerosis disease based on the severity of disability. methods: we performed a cross‑sectional cost of illness study. this study was conducted in 332 patients of ...

vitamin d has long been speculated to reduce the risk of multiple sclerosis (ms). however, its role in development and modulating the course of ms has yet to be clarified. to date, there is no scientific evidence for the use of vitamin d as monotherapy for ms in clinical practice and perplexities still exist on potential disadvantages of vitamin d intake. we hypothesize that vitamin d may be ef...

#no abstract#

background: little in known regarding the clinical relevance of sirt1 in multiple sclerosis (ms).   here, we aimed to evaluate mrna expression, protein level and enzyme activity of sirt1 in peripheral blood mononuclear cells (pbmcs) isolated from relapsing –remitting ms patients (rrms) and healthy controls. materials and methods: twenty patients with rr-ms and twenty two age- and sex-matched he...

background: neurobrucellosis is a rare complication of brucellosis. acute meningitis and encephalitis are the most common clinical manifestations; however, symptoms of these two conditions may be subacute and diagnosis requires a high index of suspicion in patients from endemic areas. diagnosis is often based on neurological symptoms, serology, and suggestive brain imaging because cerebrospinal...

background: there has been a global rising trend in recent years in the incidence of multiple sclerosis (ms). despite being an ms low-risk region, this disease has also been recently on the rise in the middle east. as part of the middle east, iran has not been spared either; however, the cause of this dramatic increase remains to be discovered. the present study reviews possible reasons for thi...

conclusions the orem-based self-care model program can be a useful tool to improve sleep quality of patients with ms. future studies can be directed to investigate the effects of such interventions on other common problems of patients. results before the intervention, there was no significant difference between the two groups with regard to mean scores of sleep quality (p = 0.22). both groups r...