In this study, we demonstrate that type VI adenylyl cyclase (ACVI) is glycosylated in vivo. Treating HEK293 cells expressing ACVI with tunicamycin to block the addition of N-linked oligosaccharide or removing the N-linked oligosaccharide by in vitro peptidyl-N-glycosidase F digestion reduced the molecular mass of ACVI. Furthermore, tunicamycin treatment suppressed the forskolin-stimulated activ...

OBJECTIVE The purpose of this study is to investigate the prognostic role of pretreatment anemia in patients with early cervical cancer who underwent radical hysterectomy. METHODS In this study, we retrospectively enrolled patients with early cervical cancer (International Federation of Obstetrics and Gynecology stage IB to IIA) who were treated at Samsung Medical Center, Seoul, Korea, from 1...

OBJECTIVE To determine the pattern of rheumatic heart disease in Aden city and surrounding areas by assessing its frequency distribution, severity and complications. METHODS We conducted this research in a sole regional echocardiographic department for Southern Yemen governorates at a referral hospital located in Aden city, from January 1999 to December 2003. It was a retrospective study focu...

To what extent can the private sector be relied upon for the protection of biological diversity? Bioprospecting, the search for valuable products such as pharmaceuticals in biological organisms, is one incentive mechanism that has received much recent attention in the literature (Polasky et al. 1993, Polasky and Solow 1995, Simpson et al. 1996, Koo and Wright 1999, Rausser and Small 2000). Simp...

A multi-laboratory collaboration is studying the feasibility of building a muon collider, the first phase of which maybe a neutrino factory. The phase space occupied by the muons is very large and needs to be cooled several orders of magnitude for either machine, 100,000 to 1 million for the collider and ten to 100 for the factory. Ionization cooling is the baseline method for muon cooling. Thi...

Fatigue has been shown to be a consistent and common problem in Parkinson’s disease (PD) in multiple countries and cultures. It is one of the most disabling of all symptoms, including motor dysfunction, and appears early, often predating the onset of motor symptoms. Several studies of the epidemiology of fatigue have been published, often using different scales, but few on treatment. The Moveme...

At the April meeting of EuroHeartCare 2016 (Athens, Greece), Dr. Barbro Kjellström (Karolinska Institute Stockholm, Sweden) showed that patients with a sustained myocardial infarction (MI) are more depressed but are less often prescribed antidepressants than people without a sustained MI. EuroHeartCare is the annual congress of the Council on Cardiovascular Nursing and Allied Professions (CCNAP...

Surveys do! We examine the forecasting power of four alternative methods of forecasting U.S. inflation out-of-sample: time series ARIMA models; regressions using real activity measures motivated from the Phillips curve; term structure models that include linear, non-linear, and arbitrage-free specifications; and survey-based measures. We also investigate several optimal methods of combining for...

BACKGROUND The efficacy of the long-pulsed diode laser (LPDL) in hair removal is determined with various physical parameters. Recently, LPDLs with a larger spot size are commercially available; however, the independent effect of spot size on hair removal has not been studied. OBJECTIVE This study aimed to compare the efficacy of the LPDL in hair removal depending on the spot size. METHODS A...

A multi-laboratory collaboration is studying the feasibility of building a muon collider, the first phase of which maybe a neutrino factory. The phase space occupied by the muons is very large and needs to be cooled several orders of magnitude for either machine, 100,000 to 1 million for the collider and ten to 100 for the factory. Ionization cooling is the baseline method for muon cooling. Thi...