Zidovudine (AZT) is one of the most referred antiretroviral drug. In spite of its higher bioavailability (50-75%) the most important reason of its cessation are bone marrow suppression, anemia, neutropenia and various organs related toxicities. This study aims at the improvement of oral delivery of AZT through its encapsulation in lactoferrin nanoparticles (AZT-lactonano). The nanoparticles (NP...

Embryotoxic factors existing in maternal sera may influence their effects via specific binding to, or alteration of cell surface molecules in the conceptus. This study was undertaken to determine the effects of sera from women with unexplained recurrent spontaneous abortion (URSA) on cell surface glycoconjugates of the early conceptus. Four cell stage embryos were cultured in medium supplemente...

This work studied the acid phosphatase (APase) activity from culture medium (extracellular, eAPase) and mycelial extract (intracellular, iAPase) of Aspergillus niger F111. The influence of fungus growth and phosphate concentration of the media on the synthesis and secretion of phosphatase was demonstrated. The effects of pH, substrate concentration and inorganic and organic compounds added to t...

Laboratory studies were conducted to determine the effects of different concentrations of Cu, Cd, Zn and mixture (equal concentrations from the three heavy metals) on growth and some oxidative stress (catalase and glutathione reductase) on Scenedesmus obliquus (microalgae) after exposure for 24, 48, and 96 h. In addition, the uptake of Cu, Cd and Zn were determined in the culture medium after 2...

Acute semistatic toxicity tests were carried out for 96h with first zoeae and young crabs of Chasmagnathus granulata. Survival curves and LC50 (lethal concentration 50, the concentration which produces the death of 50% of the exposed population) indices for copper, zinc, cadmium, and lead were determined. Furthermore, mixture toxicity tests (Cd/Cu and Cd/Zn) with first-stage larvae were also ca...

Limiting nutrient in the culture conditions is crucial for PHA production. In this study, B. thuringiensis IAM 12077 was grown in different culture conditions with limitation of potassium, nitrogen, sulphur and phosphorous. In all the limiting conditions used, a similar range of PHAs were produced with glucose as carbon source (10g/L). The PHA yields and accumulation obtained were found to be 1...

The effects of aluminum on plasma ion, lipid, protein and steroid hormone concentration were evaluated in Oreochromis niloticus broodstock females. Lipid and protein concentrations from the gonads and liver were also measured. Experiments were performed at neutral and acidic water pH. Four groups of fish were tested for 96h: 1) control conditions at neutral water pH; 2) control conditions at ac...

A trioxysalen bath is a safe alternative to systemic 8-methoxypsoralen in long-term psoralen plus ultraviolet A (PUVA) treatment. The kinetics of its main side-effect, the strong phototoxicity, has not been thoroughly studied. This study determined the degree and persistence of phototoxicity after a single 10 min bath at a trioxysalen concentration of 0.33 mg/l. The buttock skin of 16 healthy v...

Fish vaccination has been increasingly exploited as a tool to control pathogen infection. The production of immunoglobulin following vaccination might be affected by several factors such as management procedures, water temperature, and the presence of xenobiotics. In the present study, we aimed to investigate the kinetics of immunoglobulin production in silver catfish (Rhamdia quelen) inoculate...

Juvenile hybrid tilapia (Oreochromis sp.) was tested with different concentration of heavy metals under varying exposure time to examine acute toxicity effect on their survival rate and bioaccumulation in fish tissues. Copper (Cu), cadmium (Cd) and zinc (Zn) was used at rates 0.0, 0.50, 1.0, 3.0 and 5.0 mg L-1. The medial lethal concentration of Cu, Cd and Zn (96h LC50) was determined to be 0.4...