Natriuretic peptide receptor (NPR) A is composed of an extracellular domain (ECD) with a ligand binding site, a single transmembrane region, a kinase homology domain, and a guanylyl cyclase domain. The natural agonists atrial and brain natriuretic peptides (ANP, BNP) bind and activate NPRA, leading to cyclic GMP production, which is responsible for their role in cardiovascular homeostasis. Prev...

The biologically relevant arenes ethyl salicylate and salicylic amide as well the fluorescent coumarin pyrene units were functionalized with a cyclopentadiene unit. Re 99mTc complexes of latter two synthesized fully characterized. During crystallization ligands, [2+2] [6+6] cycloadditions observed for modified coumarin. A light-induced mechanism, supported by DFT calculations, is proposed these...

Native mass spectrometry (MS) and top-down electron-capture dissociation (ECD) combine as a powerful approach for characterizing large proteins and protein assemblies. Here, we report their use to study an antibody Fab (Fab-1)-VEGF complex in its near-native state. Native ESI with analysis by FTICR mass spectrometry confirms that VEGF is a dimer in solution and that its complex with Fab-1 has a...

BACKGROUND Two 99mTc-DTPA attached estrone derivatives were synthesized and their radiopharmaceutical potential was determined using female albino Wistar rats. MATERIALS AND METHODS Two novel radiolabeled estrone derivatives, 99mTc-2,2',2"2"'-(2,2'-(2-(3-methoxy-13-methyl-17-oxo-7, 8, 9, 11, 12, 13, 14, 15, 16, 7-decahydro-6H- cyclopenta[a]phenanthren-2-ylamino)-2- oxoethylazanediyl) bis(etha...

Nasu-Hakola disease is a rare, recessively inherited disease characterized by presenile dementia and bone cysts. Until now, no evidence of subclincal pathological changes in individuals heterozygous for the mutations underlying Nasu-Hakola disease has been reported. We performed a functional neuroimaging (99mTc-ECD SPECT) and neuropsychological study of healthy members of an Italian family carr...

We described a case of a 6 year old boy presenting with transient dizziness with weakness of left limbs. MRI showed the presence of a diffusely dilated extensive vascular lesion mainly located in the corpus callosum, right frontal and temporal lobes. Digital subtraction angiography (DSA) revealed a large hypervascular lesion with a diffuse arterial supply. 99mTc-ECD SPECT cerebral blood flow pe...

The study from Mehrazin et al. in HJNM 2011; 14(3): 243-50 on the neuropsychology, morphological computerized tomography (CT) and functional neuroimaging with 99mTc-labelled ethylene cysteinate dimer single-photon emission tomography (SPET) in mild traumatic brain injury (MTBI) is an interesting new approach to a disease condition which is often neglected or denied. Related to the above, we may...

OBJECTIVE The purpose of this study was to develop an imaging technique to measure and monitor tumor cells undergoing programmed death caused by radiation and chemotherapy using 99mTc-EC-annexin V. Annexin V has been used to measure programmed cell death both in vitro and in vivo. Assessment of apoptosis would be useful to evaluate the efficacy and mechanisms of therapy and disease progression ...

episode, she experienced hemidystonia o of the face and extremities, accompan motor seizures with secondary genera seizures were uncontrolled with oral anti-ep treatment for the last month and she was a hospital. On physical examination, mild faci atrophy of the left side of the body and were noticed. Laboratory data were unremark To the Editor: Dyke-Davidoff-Masson syndrom was first described ...