Alzheimer's disease (AD) is a fatal neurodegenerative disease affecting 36 million people worldwide. Genetic and biochemical research indicate that the excessive generation of amyloid-β peptide (Aβ) from amyloid precursor protein (APP), is a major part of AD pathogenesis. FE65 is a brain-enriched adaptor protein that binds to APP. However, the role of FE65 in APP processing and the mechanisms t...

A 2D Finite Element Model (F.E.M.) of chip formation process, set up with an Arbitrary Lagrangian Eulerian (A.L.E.) formulation, proposed in the software Abaqus/Explicit TM v6.3, is shown. The experimental validation showed a good qualitative agreement. Thus, FEM of cutting process can be considered as a promising and reliable tool for machining development within the near future.

1. The dye arsenazo III combines with a selection of cations to give an altered absorption spectrum. 2. Large metal cations such as Ca2+, La3+ and quadrivalent cations give a 1:1 complex with two new absorption peaks at about 610 nm and 655 nm and a KD of about 10(-6) M. 3. Aliphatic polyamines and complex cobalt ions give a 1:1 complex, with one absorption peak at about 610 nm and a KD from 10...

A software tool for automated crack onset and growth simulations based on the eXtended Finite Element Method (X-FEM) has been developed. For the first time, this tool is able to simulate arbitrary crack growth and composite delamination without remeshing. The automated tool is integrated with Abaqus/Standard and Abaqus/CAE via the customization interfaces. It seamlessly works with the Commercia...

Ultrasonic guided waves are widely used to inspect and monitor the structural integrity of plates and plate-like structures, such as ship hulls and large storage-tank floors. Recently, ultrasonic guided waves have also been used to remove ice and fouling from ship hulls, wind-turbine blades and aeroplane wings. In these applications, the strength of the sound source must be high for scanning a ...

[This corrects the article on p. 610 in vol. 6, PMID: 26347751.].

A new, computationally efficient algorithm has been implemented to solve for thermal stresses, strains, and displacements in realistic solidification processes which involve highly nonlinear constitutive relations. A general form of the transient heat equation including latent-heat from phase transformations such as solidification and other temperature-dependent properties is solved numerically...

Abstract This paper demonstrates how commercial finite-element software and optimization algorithms can be combined to fully explore the design space of thermal–mechanical metamaterials reveal trends new insight. is achieved by developing an Abaqus plugin (EasyPBC) that automates application periodic boundary conditions computes effective elastic thermal expansion properties for 2D 3D problems....

Lorentz microscopy was used to investigate the domain structure in an Fe0.5Co0.5 80Nb4B13Ge2Cu1 alloy annealed at 500, 550, and 610 °C, respectively, for 1 h. The average grain size d, observed by conventional transmission electron microscopy, is 10 nm for the alloy annealed at 500 °C, 18 nm for 550 °C, and 90 nm for 610 °C. The domain structure of sample annealed at 500 °C exhibits few pinning...