Objective: Type 2 diabetes mellitus (T2DM) is a multifactorial genetic condition caused by the combination of genes and environmental factors. Several variations linked to T2DM have been discovered in recent investigations, particularly genome-wide association studies (GWAS). This study aimed investigate involved T2DM, focusing on NGS analysis studying basis improve diagnosis, prevention, treat...

Diabetes adalah suatu keadaan adanya gangguan metabolik yang terjadi jangka panjang/kronis ditandai dengan tingginya kadar glukosa darah disebabkan oleh defisiensi insulin absolut maupun relatif, disfungsi sel β, resistensi atau dapat keduanya. melitus secara diklasifikasikan menjadi beberapa jenis, dan paling umum diketahui diabetes tipe 1 2. Faktor-faktor berhubungan angka kejadian DM diantar...

Ryojun Takeda1, Masaki Takagi1, Kentaro Miyai1, Hiroyuki Shinohara1, Hiroko Yagi2, Maki Moritani3, Ichiro Yokota3, 4, and Yukihiro Hasegawa1, 2 1 Department of Endocrinology and Metabolism, Tokyo Metropolitan Children’s Medical Center, Tokyo, Japan 2 Department of Genetic Research, Tokyo Metropolitan Children’s Medical Center, Tokyo, Japan 3 Laboratory of Pediatric Genomic Medicine, Department ...

Insecticidal activity of NK-17 was evaluated both in laboratory and in field. It was found that the toxicity of NK-17 against S. exigua was 1.93 times and 2.69 times those of hexaflumuron and chlorfluazuron respectively, and the toxicity of NK-17 against P. xylostella was 1.36 times and 1.90 times those of hexaflumuron and chlorfluazuron respectively, and the toxicity of NK-17 against M. separa...

Permanent neonatal diabetes mellitus (PNDM) is a rare condition presenting before six months of age. Mutations in the genes encoding the ATP-sensitive potassium (KATP) channel are the most common causes. Sulfonylurea (SU) therapy leads to dramatic improvement in diabetes control and quality of life in most patients who carry these mutations. Here, we report the long-term follow-up results of tw...

OBJECTIVE To describe the diagnosis of a patient with neonatal diabetes who had been misdiagnosed with type 1 diabetes and referred to our hospital for pancreas and kidney transplantation because of end-stage renal disease. RESEARCH DESIGN AND METHODS A diagnosis of neonatal diabetes was made after a molecular genetic study revealed a mutation in exon 34 of the ABCC8 gene. Pancreas transplant...

The focal form of congenital hyperinsulinism (CHI) is characterized by a cluster of abnormal insulin-oversecreting β cells within a restricted area of the pancreas. Although identification of the focal lesion is very important in the management of CHI, it has been reported that imaging studies, including computed tomography (CT), magnetic resonance imaging (MRI) scans, or angiography, are not h...

1. Anhui Biomedical Institute, Anhui Medical University, Hefei, China 2. Division of Endocrinology, the Second Hospital, Harbin Medical University, Harbin, China 3. Division of Endocrinology, the First Hospital, Harbin Medical University, Harbin, China 4. Tianjin Medical University Metabolic Hospital, Tianjin, China 5. Division of Endocrinology, Tongren Hospital, Capital Medical University, Bei...