Ginkgo biloba L. has attracted much attention due to its medicinal properties, particularly those of terpenoid and flavonoid contents. However, the content utilization efficiency terpenoids remain low. The enzyme 3-hydroxy-3-methylglutaryl CoA synthase (HMGS) is a major rate-limiting factor, RNA-seq revealed that mRNA expression this differentially expressed during biosynthesis. Here, we invest...

shen) listed in the Chinese Pharmacopoeia (CP) is widely used traditional Chinese medicine to treat coronary heart disease, cerebrovascular disease, hepatocirrhosis and against bacteria. The chemical constituents of Salvia miltiorrhiza have been studied extensively and well documented. More than 30 diterpenoid quinone pigments, particularly known as tanshinones have been isolated and identified...

THE TITLE COMPOUND [SYSTEMATIC NAME: 6β,10-dihy-droxy-1α,14α,16β-trimeth-oxy-4-methyl-7β,8-(methyl-enedi-oxy)-20-ethyl-aconitan-6-yl acetate], C(27)H(41)NO(8), is a C(19)-diterpenoid alkaloid and a major diterpenoid alkaloid component of the roots of Delphinium delavayi Franch. var. pogonanthum (Hand.-Mazz.) W. T. Wang. The mol-ecule has a lycoctonine carbon-atom skeleton with four six-membered...

While terpenoid production is generally associated with plants, a variety of fungi contain operons predicted to lead to such biosynthesis. Notably, fungi contain a number of cyclases characteristic of labdane-related diterpenoid metabolism, which have not been much explored. These also are often found near cytochrome P450 (CYP) mono-oxygenases that presumably further decorate the ensuing diterp...

A rosane type diterpenoid has been isolated from the ethyl acetate soluble fraction of Stachys parviflora. The structure elucidation was based primarily on 1Dand 2D-NMR techniques including correlation spectroscopy (COSY), heteronuclear multiple quantum coherence (HMQC), heteronuclear multiple bond correlation (HMBC), and nuclear Overhauser effect spectroscopy (NOESY). Density functional theory...

A new labdane-type diterpenoid, echinolabdane A (1), and a new sterol, 6-epi-yonarasterol B (2), were isolated from a gorgonian coral identified as Echinomuricea sp. The structures of metabolites 1 and 2 were elucidated by spectroscopic methods. Echinolabdane A (1) possesses a novel tetracyclic skeleton with an oxepane ring jointed to an α,β-unsaturated-γ-lactone ring by a hemiketal moiety, and...

A pterocarpan, 1,9-dihydroxy-3-methoxy-2-methylpterocarpan (named uncinacarpan) and two isoflavanones, 5,7-dihydroxy-2',3',4'-trimethoxy-6-(3-methylbut-2-enyl)isoflavanone (named uncinanone D) and 5,4'-dihydroxy-7,2'-dimethoxy-6-methylisoflavanone (named uncinanone E), were isolated from the CH(2)Cl(2) root extract of Desmodium uncinatum (Jacq.) DC and characterised by spectroscopic methods. In...

Two new abietane type diterpenoids, namely seco-helioscopinolide (1) and 3b,7b-dihydroxy-ent-abieta-8,13-diene-12,16-olide (2) were isolated from the aerial parts of Euphorbia formosana Hayata together with helioscopinolide A (3), helioscopinolide B (4), helioscopinolide C (5) and ent-(5b,8a,9b,10a,12a)-12-hydroxyatis-16-ene-3,14-dione (6). The structures of compounds 1-6 were elucidated by ana...