Diabetic retinopathy is a complication of type 2 diabetes resulting from long-term accumulated damage to retinal blood vessels and one the life-threatening complications most common cause acquired blindness in adults it affects 93 million people worldwide.

PURPOSE To assess the effects of retro-orbital (RO) injection of fluorescein isothiocyanate dextran (FITC-dextran) for observing mouse retinal vessels. METHODS Oxygen-induced retinopathy (OIR) was induced in 7-day postnatal (P7) C57BL/6J mice by exposing them to a 75% oxygen atmosphere for 5 days and then returning them to room air at P12. At P17, 45 P17 OIR mice and 12 normal mice received a...

The young kitten has proved to be a suitable experimental animal for studying in vivo effects of oxygen on immature retinal vessels. Visualization of these vessels by ophthalmoscopy, however, is unsatisfactory. A method is presented which affords good visualization of the retinal vessels by fluorescein angiography and which permits precise control of the intraocular pressure by use of an artifi...

PURPOSE The inhibition of angiogenesis by angiostatic steroids has been demonstrated in a variety of systems, including rabbit and rat cornea. There is considerable interest in the therapeutic potential of this class of compounds for angiogenic ocular conditions such as diabetic retinopathy, macular degeneration, and retinopathy of prematurity (ROP). This study was designed to test the capacity...

—The main cause of eye diseases in the working human is Diabetic retinopathy. Eye disease can be prevented if detects early. The extraction of blood vessels from retinal images is an essential and challenging task in medical diagnosis and analysis. This paper describes the effective and efficient extraction of blood vessels from retinal image by using Kirsch’s templates. The Kirsch’s edge opera...

T HE PHYSIOPATHOLOGY of the retinal vasculature would be better understood if more were known about blood flow in these vessels. Because of the unique quality of transparency in the eye, methods depending on direct observation of the retinal vessels seem especially inviting. Already reported by various authors are technics for measuring the changes in caliber of retinal vessels,1 and methods of...

PURPOSE Assessment of ocular involvement in transthyretin-related familial amyloidosis with polyneuropathy (FAP) in a large cohort of Portuguese patients. METHODS We reviewed the medical records of 513 Portuguese FAP mutation carriers, at the Ophthalmology Service, Centro Hospitalar do Porto, between 1 January 2008 and 31 January 2013. Abnormal conjunctiva vessels (ACV), Schirmer test, tear b...

Persistant hyperplastic primary vitreous (PHPV) was described in detail as a clinical entity by Reese1 in 1955 in his Jackson Memorial Lecture. Goldberg in his 1997 Jackson Memorial Lecture2 renamed PHPV as persistent fetal vasculature (PFV). PHPV is a pathologic entity resulting from abnormal persistence of the fetal fibrovascular primitive stroma (hyaloid system) of the eye3,4 which should di...

PURPOSE To describe a case of bilateral pigmented paravenous chorioretinal atrophy. METHODS Observational case report. RESULTS A 50-year-old female patient complained of right eye pain and decreased near visual acuity. She had a best-corrected visual acuity of 20/20 in both eyes. In the posterior segment, there were atrophic changes along retinal vessels, and bony spicule pigmentation was o...