Pharmacognosy Research,2022,14,1,100-106.DOI:10.5530/pres.14.1.14Published:December 2021Type:Original ArticleAuthors:Pankaj Kumar, Javaid Fayaz Lone, and Sumeet Gairola Author(s) affiliations:Pankaj Kumar1,2, Lone1,2, Gairola1,2,* 1Plant Sciences Division, CSIR-Indian Institute of Integrative Medicine, Canal Road, Jammu, U.T. J&K, INDIA. 2Academy Scientific Innovative Research (AcSIR), Ghaziaba...

Abrus precatorius is the native plant of India and used in many ways in the Indian Ayurvedic system of medicine. This seeds of the species is dormant due to hard seed coat. So the aim of the study is to remove seed dormancy and enhance germination capacity within a short period. To overcome the problem of dormancy, seeds were scarified by seed scarifier, sand paper, hot water treatment, DMSO an...

Abrin (ABR), a protein purified from the seeds of Abrus precatorius, induces apoptosis in various types of cancer cells. However, the detailed mechanism remains largely uncharacterized. By using a cDNA microarray platform, we determined that prohibitin (PHB), a tumor suppressor protein, is significantly upregulated in ABR-triggered apoptosis. ABR-induced upregulation of PHB is mediated by the s...

Lonchocarpine is a phenylpropanoid compound isolated from Abrus precatorius that has anti-bacterial, anti-inflammatory, antiproliferative, and antiepileptic activities. In the present study, we investigated the antioxidant effects of lonchocarpine in brain glial cells and analyzed its molecular mechanisms. We found that lonchocarpine suppressed reactive oxygen species (ROS) production and cell ...

Abrin, a member of the ribosome-inactivating protein family, is produced by the Abrus precatorius plant. Having the potential to pose a severe threat to both human and animal health, abrin is classified as a Select Agent by the U.S. Department of Health and Human Services. However, an immunoassay that is specific for intact abrin holotoxin has not yet been reported. In this study, seven new mon...

Abrin toxin is a type 2 ribosome inactivating glycoprotein isolated from the seeds of Abrus precatorius (jequirity pea). Owing to its high toxicity, relative ease of purification and accessibility, it is considered a biological threat agent. To date, there is no effective post-exposure treatment for abrin poisoning and passive immunization remains the most effective therapy. However, the effect...

Abrin, one of most potent toxins known to man, is derived from the rosary pea (jequirity pea), Abrus precatorius and is a potential bioterror weapon. The temperature and pH stability of abrin was evaluated with an in vitro cell free translation (CFT) assay, a Vero cell culture cytotoxicity assay, and an in vivo mouse bioassay. pH treatment of abrin had no detrimental effect on its stability and...