PURPOSE To examine the effects of current shunt on rats with temporal lobe epilepsy and neocortex epilepsy. EXPERIMENTAL DESIGN A kainic acid (KA)-induced model of temporal lobe seizure and a penicillin-induced model of neocortical partial seizure were used in this study. Rats of each model were randomly allocated into two groups: control and model groups. The model group was further divided ...

Benign myoclonic epilepsy in infancy (BMEI) is a rare syndrome included among idiopathic generalized epilepsies (IGE) and syndromes with age-related onset. Recently, it has been shown that a few patients with BMEI later had other epilepsy types mainly IGE but never childhood absence epilepsy (CAE). We report a patient who at 11 months of age showed isolated myoclonic jerks occurring several tim...

Review of the preand post-marketing studies of zonisamide in Japan provides valuable insight into the optimal use of this drug; in particular, its efficacy in specific seizure subtypes. After reviewing the data, Dr. Yagi has teased out some important distinctions regarding epilepsy and seizure subtypes. In particular, clinical trial results for patients who have temporal versus non-temporal lob...

The identifying characteristics of the electroencephalogram in centrencephalic epilepsy have been outlined by Penfield and Jasper (1954) as including a bilaterally synchronous onset of abnormality which consists of wave-and-spike activity at or near a frequency of 3 per second. This is in contrast to the E.E.G. abnormality seen in cases of focal cortical epilepsy in which sharp waves predominat...