518 Ann Dermatol Received April 27, 2012, Revised October 10, 2012, Accepted for publication January 13, 2013 Corresponding author: Sung Ku Ahn, Department of Dermatology, Yonsei University Wonju College of Medicine, 20 Ilsan-ro, Wonju 220-701, Korea. Tel: 82-33-741-0621, Fax: 82-33-748-2650, E-mail: ahnsk@ yonsei.ac.kr This is an Open Access article distributed under the terms of the Creative ...

Pemphigus is a group of human autoimmune blistering diseases of the skin in which autoantibodies to desmosome cadherins induce loss of cell-cell adhesion (acantholysis). In addition to steric hindrance and activation of intracellular signaling, apoptosis has been suggested to contribute to the mechanism by which pathogenic IgG induces acantholysis. We review the current literature examining the...

Imiquimod is an immunomodulator with both antitumor and antiviral properties. It is currently available in two cream formulations as Aldara (imiquimod 5%) and the newly approved Zyclara (imiquimod 3.75%). Imiquimod has been associated with localized erythema, crusting, and scaling at the site of application. However, more severe generalized skin eruptions including erythema multiforme, psoriasi...

Galli-Galli disease is a rare genodermatosis currently regarded as an acantholytic variant of Dowling-Degos disease. The 2 diseases have the same clinical features: reticular hyperpigmented macules in the great skin folds, erythematous scaly papules and plaques, comedo-like lesions, and pitted perioral scars, and the only differentiating characteristic is the histological finding of acantholysi...

SCC: squamous cell carcinoma WD: warty dyskeratoma INTRODUCTION Warty dyskeratoma (WD), also known as isolated Darier disease or focal acantholytic dyskeratosis, is a rare mucocutaneous lesion. It usually presents as a solitary, asymptomatic umbilicated papule, most often in the head and neck region of middleto older-age adults. A slight male predilection has been observed. When it occurs in th...

Primary squamous cell carcinoma of the breast is a very rare and aggressive malignancy, and very few have been reported in the literature. Here we report a case of an acantholytic variant of a squamous cell carcinoma of the breast in a 60-year-old woman who presented with a lump in the right breast. Histogenesis is controversial as to whether a pure form of squamous cell carcinoma exists or if ...