BACKGROUND Patients with chronic obstructive pulmonary disease (COPD) have increased postoperative morbidity and mortality. Epidural analgesia (EDA) improves postoperative outcome but may worsen postoperative lung function. It is unknown whether patients with COPD benefit from EDA. The objective of this study was to determine whether patients with COPD undergoing major abdominal surgery benefit...

The purpose of this study was to test two 8-year-old identical twins with ectodermal dysplasia (ED) and their unaffected parents for the presence of mutations in the EDA gene with the hypothesis that they might be carrying a de novo mutation in EDA and potentially eligible for recombinant EDA therapy. DNA was extracted using saliva samples obtained from the identical twin girls and both parents...

Phosphate was captured from aqueous solutions by cationic metal-EDA complexes anchored inside mesoporous silica MCM-41 supports (Cu(II)-EDA-SAMMS and Fe(III)-EDA-SAMMS). Fe-EDA-SAMMS was more effective at capturing phosphate than the Cu-EDA-SAMMS and was further studied for matrix effects (e.g., pH, ionic strength, and competing anions) and sorption performance (e.g., capacity and rate). The ad...

INTRODUCTION Hypodontia, hypohidrosis, sparse hair and characteristic faces are the main characters of X-linked hypohidrotic ectodermal dysplasia (XLHED) which is caused by genetic ectodysplasin A (EDA) deficiency. Heterozygous female carriers tend to have mild to moderate XLHED phenotype, even though 30% of them present no obvious symptom. METHODS A large Chinese XLHED family was reported an...

This paper summarizes a strategy for development of an EDA (Electronic Design Automation) tool which is aimed to support the design of future nano-circuits. The problem with the existing EDA tools is that they do not explicitly consider reliability as a design criterion. Most of the tools that do consider reliability are not intended for the nanoelectronic industry and are very limited in the t...

The mouse hair coat comprises protective "primary" and thermo-regulatory "secondary" hairs. Primary hair formation is ectodysplasin (Eda) dependent, but it has been puzzling that Tabby (Eda(-/y)) mice still make secondary hair. We report that Dickkopf 4 (Dkk4), a Wnt antagonist, affects an auxiliary pathway for Eda-independent development of secondary hair. A Dkk4 transgene in wild-type mice ha...

X-linked hypohidrotic ectodermal dysplasia (XLHED) is the most common of the ectodermal dysplasias, with a classic presentation of hypodontia, hypohidrosis, hypotrichosis and secretory gland hypoplasia. Mutations in the ectodysplasin gene (EDA) underlie XLHED with nearly 200 different mutations reported. EDA encodes a type 2 transmembrane protein of the TNF family (EDAA1), the active form of wh...

Hypohydrotic Ectodermal Dysplasia (HED) is a genetic disease seen in humans and mice. It is characterized by loss of hair, sweat glands, and teeth. The predominant X-linked form results from mutations in ectodysplasin-A (EDA), a TNF-like ligand. A phenotypically indistinguishable autosomal form of the disease results from mutations in the receptor for EDA (EDAR). EDAR is a NF-kappaB-activating,...

Statistical analysis is generally seen as the next EDA technology for timing and power sign-off. Research into this field has seen significant activity started about five years ago. Recently, interest appears to have fallen off somewhat. Also, while a lot of focus has been put on research fundamentals, extremely few applications in industry have been reported so far. Therefore, a group includin...