A series of some novel diarylsulfonylurea-chalcone hybrids synthesized in our earlier study as potential 5lipoxygenase inhibitors were now subjected for the anti-inflammatory activity by using carrageenan induced rat paw edema method. The compounds 4o, 4q, 4r, 4t and 4y were selected for the study; the rationale behind the selection of these compounds is mainly due to their potential inhibitory...

Colchicine is used mainly for the treatment of gout and familial mediterranean fever. The use of colchicine is limited by its toxicity, and colchicine overdose is associated with a high mortality rate. Herein, we are reporting a young man who presented to the emergency department after ingesting 13.5 mg of colchicine and 1200 mg of aceclofenac (non-steroid anti-inflammatory drug) for deliberate...

The article discusses the clinical manifestations, pathomorphology, pathogenesis and various treatment methods of cervical radiculopathy (CR). Article points out diagnostic difficulties arising from frequent discrepancy between neuroimaging data. issues choice conservative surgical are discussed, based on analysis data recent systematic reviews. In absence focal neurological symptoms, radicular...

Plenty of natural polymers has been found effective to modulate the drug release. Numerous either alone or in combination with other were controlling In current study attempts made combine chitosan (degree deacetylation 88.42 %, Molecular weight 50,000 Da, and viscosity 93 CPS) HPMC K 15M retard release aceclofenac tablet formulation. The tablets prepared by wet granulation method evaluated for...