Alcohol is a major cause of both acute and chronic pancreatitis. Activated pancreatic stellate cells (PSCs) have recently been implicated in the pathogenesis of pancreatic inflammation and fibrosis. Herein, we examined the effect of ethanol and acetaldehyde on the activation of transcription factors and mitogen-activated protein (MAP) kinases in PSCs. PSCs were isolated from rat pancreas tissue...

Background: Excessive alcohol consumption can cause a variety of long-term sequelae like damages to the nervous system and liver or cancer. For the latter, Acetaldehyd is regarded as carcinogenic noxa. While Acetaldehyde adducts of hemoglobin have been considered as potential biochemical markers of ethanol exposure a chemical identification in human blood samples has not been achieved. Method: ...

The MP2 and DFT/B3LYP methods at 6-311++G(d,p) and aug-cc-pdz basis sets have been used to probe the origin of relative stability preference for eclipsed acetaldehyde over its bisected counterpart. A relative energy stability range of 1.02 to 1.20 kcal/mol, in favor of the eclipsed conformer, was found and discussed. An NBO study at these chemistry levels complemented these findings and assigne...

Alcoholism has been associated with folate deficiency in humans and laboratory animals. Previous study showed that ethanol feeding reduces the dehydrogenase and hydrolase activity of 10-formyltetrahydrofolate dehydrogenase (FDH) in rat liver. Hepatic ethanol metabolism generates acetaldehyde and acetate. The mechanisms by which ethanol and its metabolites produce toxicity within the liver cells...

LaAlO3 perovskites, as such and with 25% molar Al substitution by Cu, Co, or Ga, have been prepared sol-gel methods tested heterogeneous catalysts in the gas-phase conversion of ethanol. presented a significant acidic character, high formation ethylene ethanol dehydration. B-site substitutions increased basicity catalysts, favoring dehydrogenation to acetaldehyde. The most reducible Cu- Co-subs...