We describe an unconventional response of intracellular pH to NH4Cl in mouse cerebral astrocytes. Rapid alkalinization reversed abruptly to be replaced by an intense sustained acidification in the continued presence of NH4Cl. We hypothesize that high-velocity [Formula: see text] influx persisted after the distribution of ammonia attained steady state. From the initial rate of acidification elic...

Atmospheric carbon dioxide (CO(2)) is increasing at an accelerating rate, primarily due to fossil fuel combustion and land use change. A substantial fraction of anthropogenic CO(2) emissions is absorbed by the oceans, resulting in a reduction of seawater pH. Continued acidification may over time have profound effects on marine biota and biogeochemical cycles. Although the physical and chemical ...

Many mitogens cause rapid changes in intracellular pH and Ca2+. We studied the patterns of pH and Ca2+ changes after exposure of murine fibroblasts to platelet-derived growth factor (PDGF), bombesin, phorbol 12-myristate 13-acetate (PMA), and the vasoactive peptide bradykinin. Intracellular pH and Ca2+ were measured by using the fluorescent dyes 2',7'-bis(carboxyethyl)-5(6)-carboxyfluorescein a...

In recent years, increasing the awareness on the environmental problems, especially global warming, has increase the concerns about the impact of emissions on the global climate. The current study was conducted to evaluate and analyze the environmental effects of rapeseed production in the form of life cycle using SimaPro software with the aim concentration on climate changes and impact of acid...

Insulin secretion from pancreatic beta cells is dependent on maturation and acidification of the secretory granule, processes necessary for prohormone convertase cleavage of proinsulin. Previous studies in isolated beta cells revealed that acidification may be dependent on the granule membrane chloride channel ClC-3, in a step permissive for a regulated secretory response. In this study, immuno...

Artificial ocean alkalinization (AOA) is investigated as amethod tomitigate local ocean acidification and protect tropical coral ecosystems during a 21st century highCO2 emission scenario. Employing an Earth systemmodel of intermediate complexity, our implementation of AOA in theGreat Barrier Reef, Caribbean Sea and SouthChina Sea regions, shows that alkalinization has the potential to countera...

The possibilities for interactions between toxicants and ocean acidification are reviewed from two angles. First, it is considered how toxicant responses may affect ocean acidification by influencing the carbon dioxide balance. Second, it is introduced, how the possible changes in environmental conditions (temperature, pH and oxygenation), expected to be associated with climate change and ocean...

http://www.jimmunol.org/content/184/3/1200 doi:10.4049/jimmunol.0902584 December 2009; 2010;184;1200-1209; Prepublished online 21 J Immunol Reinhard Andreesen, Eva Gottfried and Marina P. Kreutz Kastenberger, Leoni A. Kunz-Schughart, Peter J. Oefner, Karin Eberhart, Christoph Dorn, Claus Hellerbrand, Michael Katrin Dietl, Kathrin Renner, Katja Dettmer, Birgit Timischl, Secretion and Glycolysis ...

Citation: Zark M, Broda NK, Hornick T, Grossart H-P, Riebesell U and Dittmar T (2017) Ocean Acidification Experiments in Large-Scale Mesocosms Reveal Similar Dynamics of Dissolved Organic Matter Production and Biotransformation. Front. Mar. Sci. 4:271. doi: 10.3389/fmars.2017.00271 Ocean Acidification Experiments in Large-Scale Mesocosms Reveal Similar Dynamics of Dissolved Organic Matter Produ...