Wilson's disease (WD) is a rare inherited disorder of copper metabolism and the main manifestations are liver and brain disorders. Hemolytic anemia is an unusual complication of WD. We describe a 15-year-old girl who developed hemolytic anemia as the first manifestation of Wilson's disease. An Arg952Lys mutation was found in exon 12 of the ATP7B gene, which is uncommon among Chinese Han individ...

By ULFAR JONSSON, M.D., 0. C. HANSEN-PRUSS, M.D., AND R. W. RUNDLES, M.D. T HERE have been many reports in recent years of splenectomy for hemolytic anemia, thrombocytopenia, or pancytopenia resulting from vascular, infectious, or neoplastic involvement of the spleen.” 12, 13, 15 Hemolytic anemia has been observed in a few patients with leukemic splenomegaly) 6. 8. 13, 15 The leukemia has usual...

Auto-immune hemolytic anemia (AIHA) has an extensive differential diagnosis though Hodgkin’s lymphoma (HL) is not always an obvious diagnosis. AIHA can precede the diagnosis of HL for several years. In adults the association of AIHA and HL is more frequent in advanced stages of HL. Warm immune hemolytic anemia is mainly controlled with steroids and chemotherapy. We report a case of a patient wi...

introduction: severe acquired aplastic anemia (saa) is a rare disease and matched related hematopoietic stem cell transplantation (hsct) is the treatment of choice especially in pediatric patients. immunosuppressive therapy is the alternative treatment in patients who do not have a donor. we retrospectively analyzed patients who received allogeneic hsct at our institution. methods: between 1991...

Natural resistance-associated macrophage protein 1 (Nramp1) is a divalent metal transporter expressed exclusively in phagocytic cells. We hypothesized that macrophage Nramp1 may participate in the recycling of iron acquired from phagocytosed senescent erythrocytes. To evaluate the role of Nramp1 in vivo, the iron parameters of WT and KO mice were analyzed after acute and chronic induction of he...