INTRODUCTION The 'order of draw' has been advocated since 1982 to reduce the risk of cross-contaminating blood tubes with additives from a previously filled tube. METHODS We studied 193 patients receiving oral anticoagulation. Multiple tubes were collected in a specific order using the Sarstedt Safety Monovette System. We evaluated the effect of the 'order of draw' on the prothrombin time/int...

Two polysaccharides were isolated successfully from Flammulina velutipes and identified as CHFVP-1 (24.44 kDa) CHFVP-2 (1497 kDa). Based on the results of Fourier transform-infrared spectroscopy (FT-IR), gas chromatography (GC), chromatography–mass spectrometry (GC–MS), nuclear magnetic resonance (NMR) regarding structure CHFVP-2, was constructed with backbone of?6)-?-D-Galp-(1? branch Galp by ...

This retrospective, descriptive study aimed to assess hematologic testing practices in 100 patients with preeclampsia undergoing neuraxial blockade (NB). Prior to NB, platelet (PLT) count was performed in 61 (98%) of 62 women in labor and in 37 (97%) of 38 women undergoing cesarean delivery (CD). No patients had a pre-NB PLT count <70 × 10(9)/L. Pre-NB tests for prothrombin time (PT) and activa...

BACKGROUND In critically ill patients, dosing of unfractionated heparin (UFH) is difficult due to unpredictable pharmacokinetics, which has an impact on the time to reach therapeutic anticoagulation. We evaluated the quality of UFH therapy in critically ill patients in terms of activated partial thromboplastin time (APTT) test values and time to therapeutic range. METHODS Patients admitted to...

OBJECTIVE To determine the coagulation abnormalities and relationship between abnormal clotting tests and the risk of gastrointestinal bleeding (GI) among chronic liver disease (CLD) patients admitted at a tertiary care hospital in Pakistan. METHODS Adult CLD patients admitted at Liaquat University Hospital Jamshoro, during Nov 2004-Oct 2005, were included in the study. The patients blood wer...

BACKGROUND Laboratory tests to assess novel oral anticoagulants (NOACs) are under evaluation. Routine monitoring is unnecessary, but under special circumstances bioactivity assessment becomes crucial. We analyzed the effects of NOACs on coagulation tests and the availability of specific assays at different laboratories. METHODS Plasma samples spiked with dabigatran (Dabi; 120 and 300 μg/L) or...

Introduction Factor dosages are part of the diagnostic work up in patients with bleeding tendency (factor (F) VIII and FIX) or in thrombophilia screening (FVIII). The correct diagnosis of FVIII and FIX deficiency and the assessment of severity of the disease are essential for a patient-tailored treatment strategy. Persistently high levels of FVIII are regarded as a thrombophilia risk marker. FV...

INTRODUCTION We report the effect of temperature and storage duration on a range of haematological analytes: activated partial thromboplastin time (APTT), D-dimers, fibrinogen (Fbg), prothrombin time (PT) and thrombin time (TT). All analytes were measured using a Sysmex CA7000 System with SIEMENS reagents. METHODS One hundred and sixty patients were divided into two groups: samples from group...

Rodent ovariectomy is an experimental method to eliminate the main source of sexual steroids. This work explored for the first time the ovariectomy temporal changes induced in the hemostatic coagulation markers: prothrombin time (PT), activated partial thromboplastin time (aPTT), thrombin time (TT), and fibrinogen concentration (FIB) along with uterine weight on adult female CD1 mice and Wistar...