نتایج جستجو برای: active links 191
تعداد نتایج: 526750 فیلتر نتایج به سال:
Background and Aim: According to the latest estimate published by the World Health Organization in 2017, there are 219 million malaria cases and 435,000 deaths. With the emergence of drug-resistant strains in malaria, there is a need for new drug targets every time. In this study, the design and docking study of the pyrimidine derivatives for inhibiting Methionine aminopeptidase1B enzyme (Metap...
Binding to the CD4 receptor induces conformational changes in the human immunodeficiency virus (HIV-1) gp120 exterior envelope glycoprotein. These changes allow gp120 to bind the coreceptor, either CCR5 or CXCR4, and prime the gp41 transmembrane envelope glycoprotein to mediate virus-cell membrane fusion and virus entry. Soluble forms of CD4 (sCD4) and small-molecule CD4 mimics (here exemplifie...
Hepatocellular carcinoma (HCC) is generally a fatal disease due to a paucity of effective treatment options. The identification of oncogenic microRNAs that exert pleiotropic effects in HCC cells may offer new therapeutic targets. In this study, we have identified the human microRNA miR-191 as a potential target for HCC therapy. Inhibition of miR-191 decreased cell proliferation and induced apop...
The mutagenicity of six heterocylic nitrogen mustards (ICR compounds) has been determined in a cultured mammalian cell system by use of resistance to the purine analog 6-thioguanine to select for mutation induction at the hypoxanthine-guanine phosphoribosyltransferase locus in Chinese hamster ovary cells. The six compounds tested are ICR 191, 170, 292, 372, 191-OH, and 170-OH. The first four co...
The links between active cooperation and eco‐innovation orientation of firms: A multi‐analysis study
The environmental orientation of companies is key for firms to gain a competitive advantage against peers. However, the high level novelty and uncertainty involved with eco-innovations requires additional knowledge capabilities that go beyond firm can be achieved through cooperation. Thus, it crucial analyse how cooperation affects elements drive eco-innovation. This study tests impact on while...
Perspectives on the application of technology to enhance learning in an undergraduate nursing degree programme Original Citation Perspectives on the application of technology to enhance learning in an undergraduate nursing degree programme. Nurse Education Today. Users may access full items free of charge; copies of full text items generally can be reproduced, displayed or performed and given t...
We have defined a model for multidimensional hyperpresentations, in which time-varying multimedia presentations are dynamically linked together. In our model a hyperlink’s context can change over time. Thus, at any time during a continuous presentation, a user can interactively access context-specific information. How the hyperlinks are traversed depends upon user interaction and/or context-sen...
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