In this paper, we present GateScript, a scripting language for active applications to be executed on generic active gateways. Unlike other active networking platforms, it offers a simple scripting language for expressing custom processing of packets at different protocol layers without the need for interpretation of complex protocol data structures. In this way, the user writes statements in a ...

About 10% of all protein kinases are predicted to be enzymatically inactive pseudokinases, but the structural details of kinase inactivation have remained unclear. We present the first structure of a pseudokinase, VRK3, and that of its closest active relative, VRK2. Profound changes to the active site region underlie the loss of catalytic activity, and VRK3 cannot bind ATP because of residue su...

An active database consists of a collection of event-condition-action rules (or ECA-rules), some meta rules that specify the desired interactions and constraints for the execution of rable rules, and a traditional database. The main goal of an active database is to automatically manage database operations. In general, the occurrence of an event can cause several rules to be rable nondeterminist...

The expressiveness and complexity of several active database prototypes are formally studied. First, a generic framework for the spec-iication of active databases is developed. This factors out the common aspects of the prototypes considered, and allows studying various active database features independently of any speciic prototype. Furthermore, each of the prototypes can be speciied by specia...

We have defined the histone acetylation pattern of the endogenous murine beta-globin domain, which contains the erythroidspecific beta-globin genes. The beta-globin locus control region (LCR) and transcriptionally active promoters were enriched in acetylated histones in fetal liver relative to fetal brain, whereas the inactive promoters were hypoacetylated. In contrast, the LCR and both active ...

Recently, mutations of the active site Lys296 residue in rhodopsin (Lys296-->Glu and Lys296-->Met) have been found as the cause of disease in some patients with autosomal dominant retinitis pigmentosa. In vitro, these mutations result in constitutive activation of the protein. In an effort to develop a potential therapeutic agent for treatment of the disease, we have examined various amine deri...

Discovering rare categories and classifying new instances of them is an important data mining issue in many fields, but fully supervised learning of a rare class classifier is prohibitively costly. There has therefore been increasing interest both in active discovery: to identify new classes quickly, and active learning: to train classifiers with minimal supervision. Very few studies have attem...