OBJECTIVE To determine the frequency and pattern of Hepatitis B and C over the past twenty one years, in a liver research unit of Karachi. METHODS Retrospective analysis of the records of PMRC, Research Centre, Jinnah Postgraduate Medical Centre, Karachi, from 1987 to 2007 were reviewed. A special flow sheet was made where information of all patients with viral liver disease was entered. Pati...

In Bangladesh and in most parts common causes of acute hepatitis include hepatitis viruses, alcohol and drugs. However less common aetiologies like Wilson’s disease must be kept in mind and looked for, whenever there is strong suspicion. Here we present a young male who presented to us with classic features of acute hepatitis including prodrome and on evaluation was diagnosed as a case of acute...

The epidemiologic status of leptospirosis in Egypt has not been well defined because of difficulties in disease diagnosis. A retrospective study was conducted to detect leptospiral antibodies among undiagnosed acute febrile illness (AFI) and hepatitis cases. Approximately 16% of both AFI (141/886) and acute hepatitis (63/392) cases showed seroreactivity to Leptospira IgM by ELISA and microscopi...

Fifty cases of sporadic acute viral hepatitis were studied for various hepatitis markers. There was only one case of hepatitis A. Eight percent of the acute cases were due to hepatitis B but 48% of the patients showed evidence of exposure to B virus. Seventy Six percent of the cases were due to hepatitis non-A, non B. This is the commonest type in our study. The incidence of this form of hepati...

A. Acute Infective Hepatitis (i) The pre-icteric phase, with pyrexia and intestinal manifestations dominating the picture. (ii) The icteric phase, with jaundice as the dominant manifestation. The type varies from the fulminating to the average type of case with jaundice lasting two to three weeks. (iii) The post-hepatitis syndrome, the stage of symptoms without signs. (iv) Infective hepatitis w...

BACKGROUND In inmunocompetent hosts, cytomegalovirus (CMV) infection is generally asymptomatic. It may however present as infectious mononucleosis. Serious complications have rarely been reported. We report three cases of acute CMV hepatitis in immunocompetent men for the first time from Bangladesh. All three presented to us with features of acute hepatitis of variable duration preceded by prod...

Liver biopsy plays a central role in treatment algorithms in patients with hepatitis B and remains the gold standard for evaluating hepatic pathology. The pathology of hepatitis B is diverse and reflects the natural history of infection. An acute hepatitic pattern with lobular disarray is seen in acute infection, during acute flares of disease, and with acute hepatitis D superinfection. In chro...

Serum levels of hepatitis B virus specific DNA polymerase and hepatitis B e antigen were studied serially in 34 patients with hepatitis B virus infection--20 who had the acute illness and recovered, seven who died with fulminant disease, three who died as a result of subacute hepatic necrosis, and four who went on to develop chronic active hepatitis. DNA polymerase activity was present in 16 (8...