Systematic gait analyses have been widely used in clinical settings as a reliable means of evaluating stroke severity and the efficacy of rehabilitation on people. However, the extent of gait changes post-stroke in experimental quadrupeds remains to be explored. To date, gait studies in cerebral ischemia have been limited to the mild ischemia-reperfusion model. However, studies on pathophysiolo...

BACKGROUND Studies show S100 as a possible acute ischemic stroke (AIS) marker. OBJECTIVES Determine (1) whether S100 serum concentrations correlate with stroke symptom onset, infarction volume, stroke severity, functional outcome, or length of hospital stay; (2) whether S100 serial measurements are useful markers for ongoing brain ischemia, and (3) whether S100 levels at various time interval...

BACKGROUND AND PURPOSE The sensitivity of the brain to brief periods of profound ischemia or prolonged periods of modest ischemia mandates an aggressive approach to acute stroke care. Past studies have shown that many stroke patients do not receive acute care in an urgent and timely fashion. The formation of acute stroke teams (AST) is one approach that can be used to accelerate the delivery of...

BACKGROUND AND PURPOSE Several studies have implied an association between Chlamydia pneumoniae and atherosclerosis. Our research was designed to investigate the association of this organism with strokes and transient cerebral ischemia. METHODS Antibodies to C pneumoniae were measured in 176 patients with stroke or transient cerebral ischemia and 1518 control subjects with noncardiovascular, ...

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We examined the influence of left ventricular end-diastolic pressure (LVEDP) on the mechanical interaction between ischemic and nonischemic areas during acute myocardial ischemia. Circumferentially oriented ultrasonic segment gauges were implanted in the midwall of the anterior apex and posterior apex of the left ventricle in seven anesthetized dogs. Stroke volume was measured with a flow probe...

BACKGROUND AND PURPOSE Although various revascularization scales are used in the angiographic evaluation of acute ischemic stroke, observer reliability tests of these scales have been rarely performed for posterior circulation stroke. We aimed to evaluate inter- and intraobserver variability of 2 scales, the modified Treatment in Cerebral Ischemia and the Arterial Occlusive Lesion, in posterior...

OBJECTIVE To describe the distribution of steno-occlusive disease and the associated rate of recurrence in patients with acute cerebral ischemia. DESIGN An inception cohort was prospectively recruited after an index event and followed up to assess recurrent stroke and death up to 1 year after the event. SETTING Eleven German departments of neurology with acute stroke units. PATIENTS A tot...

In a clinical study conducted a decade ago, it was proposed that different versions of the gene encoding phosphodiesterase 4D, cAMP-specific (pde4d) confer different risks for ischemic stroke. Today, however, there continues to be unresolved global discussion of this issue. This short review summarizes the results of clinical genomic and basic research studies. In the acute phase following expe...

Background and Purpose: Diffusionand perfusion-weighted imaging (DWI/PWI) of acute ischemic stroke can be used to identify the ischemic core (DWI) and to estimate the penumbral tissue (PWI-DWI mismatch) which is at risk of infarction but is potentially salvageable. MRI of sodium, a marker of ionic homeostasis that is disrupted after ischemia, within the lesion may be complementary by indicating...