Disease recurrence following successful remission induction by polychemotherapy or bone marrow transplantation represents a major clinical problem in the treatment of leukemia patients. Sensitive methods for the identification of neoplastic cells escaping therapeutic interventions and potentially causing relapse are important for the monitoring of therapeutic effectiveness. The in vitro amplifi...

background: acute lymphoblastic leukemia (all) is the most common form of childhood cancer leading to cancer-related death in children. most infants with all harbor recurring structural chromosomal rearrangements that are important initiating events in leukemogenesis but are insufficient to explain the biology and heterogeneity of the disease. mixed-lineage leukemia-rearrangement (mll-rearrange...

calcium metabolic disorders, such as hypercalcemia is a potentially life-threatening disorder especially when coupled with an already compromised condition. the aim of this study was to determine the prevalence of metabolic calcium disorders in childhood cancers of patients admitted to the pediatric ward of vali-asr hospital from the year 2001-2008. the study was carried out by reviewing hospit...

The in vitro granulocyte colony-forming remission were serially studied during reability of bone marrow from 19 patients mission. Normal in vitro colony formation with acute myelocytic leukemia (AML) was ensued in five of the eight patients studied. studied at the time of initial diagnosis and Three patients did not produce normal serially. Initially 1 8 of the 1 9 patients grew numbers of colo...

Considering the high prevalence of acute myelocytic leukemia in adults, understanding pathophysiology this disease and investigating cytogenetic markers play an important role dealing with for its classification, timely diagnosis, prognosis predicting response to treatment process. The aim study was investigate molecular status patients Kurdistan region Iraq. This conducted 2021 on 40 referred ...

Autoimmune hemolytic anemia (AIHA) has been described in patients with lymphoid neoplasm with an etiologic relationship between the emergence of autoantibodies and lymphocyte dysfunction. Autoimmune disorders are less to develop in patients with other neoplasm like chronic myeloid leukemia, myelodysplastic syndrome or acute myeloid leukemia. Few reports have been documented the development of i...

A 46-year-old man was referred for acute myelocytic leukemia (AML) and pneumonia. On admission, physical examination findings included high fever and hepatosplenomegaly. The peripheral blood count results were as follows: hemoglobin level, 7.9 g/dL; platelet count, 7 3 10/L; and white blood cell count, 17.8 3 10/L (blasts, 37%). Bone marrow aspiration showed a hypercellular marrow with 60% myel...

Since 1980, adults with acute myelocytic leukemia (AML) have been treated on two clinical studies using intensive timed sequential therapy. All patients ages 16 to 80, including those with secondary AML (SAML) and those with AML preceded by a hematologic disorder (AHD), were treated, regardless of medical complications at the time of diagnosis. The first study combined high doses of cytarabine ...