In a previous study of acute leukemia, we have shown that WT1 gene mutations occur in both myeloid and biphenotypic subtypes, where they are associated with refractoriness to standard induction chemotherapy. We have now extended this study to a total of 67 cases (34 acute myeloid leukemia [AML], 23 acute lymphoblastic leukemia [ALL], 10 acute undifferentiated leukemia [AUL]/biphenotypic) and fi...

Aim: The objective of this work was to investigate the prognostic role HMGN family in acute myeloid leukemia (AML). Methods: A total 155 AML patients with HMGN1–5 expression data from Cancer Genome Atlas database were enrolled study. Results: In chemotherapy-only group, high HMGN2 had significantly longer event-free survival (EFS) and overall (OS) than those low (all p < 0.05), whereas HMGN5...

Somatic mutations in isocitrate dehydrogenase 1 and 2 (IDH1 and IDH2) were recently demonstrated in acute myeloid leukemia (AML), but their prevalence and prognostic impact remain to be explored in large extensively characterized AML series, and also in various other hematologic malignancies. Here, we demonstrate in 893 newly diagnosed cases of AML mutations in the IDH1 (6%) and IDH2 (11%) gene...

Evaluation of ATG7 and LC3 Autophagy Genes Expression in Newly Diagnosed AML patients Background and aim: Autophagy, known as cell death type II, is a housekeeping pathway that currently has been worked on in matters of tumorigenesis and leukemogenesis. Therefore, in this study expression levels of ATG7 and LC3 as two key genes are targeted in AML patients. Material and method: This...

Nano Cell Cycle Checkpoint Inhibitors In article number 2300736, Daishun Ling, Fangyuan Li, and co-workers demonstrate that ultra-small iron oxide nanoparticles (IONPs) can serve as a selective nano cell cycle checkpoint inhibitor (NCCI) to catalyze the intracellular H2O2 into abundant ·OH, cleave heat shock protein 90 (Hsp90), thus induce degradation of client ATR/CHK1, leading dysfunction G2/...

calcium metabolic disorders, such as hypercalcemia is a potentially life-threatening disorder especially when coupled with an already compromised condition. the aim of this study was to determine the prevalence of metabolic calcium disorders in childhood cancers of patients admitted to the pediatric ward of vali-asr hospital from the year 2001-2008. the study was carried out by reviewing hospit...

AML: acute myeloid leukemia irAEs: immune-related adverse events PD-1: programmed cell deathe

Differentiation inhibitory factor (nm23 protein) inhibited the induction of differentiation of mouse myeloid leukemia M1 and WEHI-3BD+ and human erythroleukemia HEL, KU812, and K562 cells. Block of differentiation may be associated with the aggressive behavior of leukemia. To examine the role of nm23 in human myeloid leukemia, we investigated the relative levels of nm23-H1, nm23-H2, and c-myc t...

This study investigates whether serum D-2HG (D-2-hydroxyglutarate) produced by the mutated isocitrate dehydrogenase (IDH) can predict IDH mutations in acute myeloid leukemia (AML) at diagnosis. and L-2HG are measured liquid chromatography-tandem mass spectrometry. D-2HG, total 2HG D/L ratio (D-2HG/L-2HG) significantly higher IDHmutated cases than IDHwild cases. The optimal cutoff values to 100%...

Acute myeloid leukemia (AML) is the most common among adult population and accounts for about 80% of all cases, its characterized by clonal expansion immature “blast cells” in peripheral blood bone marrow .The stem cell marker CD34 expressed blasts only a subset patients with acute myelogenous (AML).The aim this study to determine role AML relationship parameters complete (CBC). A total (60) ve...