The acute phase reaction is a natural response to tissue injury and includes a range of metabolic activities which include alterations in the rate of synthesis of several proteins produced by the liver. It is recognised that the cytokines play a key role in mediating this response. Research is directed toward an understanding of this response from the stimulus through mediation to the role of t...

The acute-phase response is an inflammatory process triggered mainly by the cytokine IL-6. Signaling of IL-6 is transduced by activation of STAT3 (signal transducer and activator of transcription 3), which rapidly induces the production of acute-phase proteins such as haptoglobin and fibrinogen. Another target of the IL-6/STAT3 signal transduction pathway is the microRNA cluster miR-17/92. Here...

introduction : intestinal ischemia and reperfusion (i-i/r) is an insult associated with acute respiratory distress syndrome (ards). herein we evaluate the dose-response effect of low-level laser therapy (lllt) on lung inflammation induced by i-i/r. methods : mice were subjected to mesenteric artery occlusion (45 min) and killed after clamp release and intestinal reperfusion (2h). increasing dos...

BACKGROUND Goat caseous lymphadenitis (CLA) is a chronic disease caused by Corynebacterium pseudotuberculosis. However, there is paucity of data about goat's acute phase response during the course of CLA. This study was conducted to investigate the response of acute phase proteins, mainly haptoglobin (Hp), serum amyloid A (SAA) and the negative acute phase response, especially albumin after an ...

The immune response against the infecting group A streptococcus (GAS) extracellular products (EP) was determined in acute- and convalescent-phase sera from 75 patients with different clinical manifestations of GAS infection. All EP elicited a high proliferative response in human peripheral blood mononuclear cells. In patients with bacteremia, low neutralization in acute-phase sera was associate...

BACKGROUND In patients with major trauma and burns, total enteral nutrition (TEN) significantly decreases the acute phase response and incidence of septic complications when compared with total parenteral nutrition (TPN). Poor outcome in acute pancreatitis is associated with a high incidence of systemic inflammatory response syndrome (SIRS) and sepsis. AIMS To determine whether TEN can attenu...

Introduction: Although formalin-induced activity in primary afferent fibers and spinal dorsal ‎horn is well described, the midbrain neural basis underlying each phase of behavior in ‎formalin test has not been clarified. The present study was designed to investigate the nucleus ‎cuneiformis (CnF)‎‏ ‏neuronal responses during two phases after subcutaneous injection of ‎formalin into the hind paw...

Acute phase proteins have been studied widely in human medicine, especially as biomarkers of diseases, inflammatory processes and various infections, to diagnose and monitor the success of diseases, as well as to follow-up the treatment in clinical praxis (Hilliquin, 1995; Deans & Wigmore, 2005; Endre & Westhuyzen, 2008). However, the possible influence of inflammatory conditions on the concent...