Background Clinical implementation of novel blood-based biomarkers for Alzheimer’s disease (AD) will aid in accurate, less-invasive diagnosis. However, variation blood handling may affect the accuracy biomarker’s measurement. Establishing standardized operating procedures (SOPs) to mitigate these effects is essential implementing into clinical use. We aim provide an evidence-based SOP specific ...

Alzheimer's disease (AD) is characterized by the presence of toxic protein aggregates or plaques composed of the amyloid β (Aβ) peptide. Various lengths of Aβ peptide are generated by proteolytic cleavages of the amyloid precursor protein (APP). Mutations in many familial AD-associated genes affect the production of the longer Aβ42 variant that preferentially accumulates in plaques. In the case...

OBJECTIVE To determine whether beta-amyloid (Abeta) peptides segregated into distinct biochemical compartments would differentially correlate with clinical severity of Alzheimer disease (AD). DESIGN Clinicopathologic correlation study. PARTICIPANTS Twenty-seven patients from a longitudinal study of AD and 13 age- and sex-matched controls without a known history of cognitive impairment or de...

Accumulation of amyloid(A ) peptides in the brain has been suggested to be the primary event in sequential progression of Alzheimer’s disease (AD). Here, we use Drosophila to examine whether expression of either the human A 40 or A 42 peptide in the Drosophila brain can induce pathological phenotypes resembling AD. The expression of A 42 led to the formation of diffused amyloid deposits, age-de...

INTRODUCTION The Alzheimer Disease (AD) is the most common form of dementia that leads to memory impairment. As the oxidative stress plays an important role in AD pathogenesis, the current study aimed at examining the protective effects of Cyperus Rotundus as an antioxidant on amyloid β (Aβ)-induced memory impairment. METHODS Twenty-eight Wistar male rats received intrahippocampal (IHP) injec...

Alzheimer's disease (AD) etiological studies suggest that an elevation in amyloid-β peptides (Aβ) level contributes to aggregations of the peptide and subsequent development of the disease. The major constituent of these amyloid peptides is the 1 to 40-42 residue peptide (Aβ(40-42)) derived from amyloid protein precursor (APP). Most likely, reducing Aβ levels in the brain may block both its agg...

A learner who can solve a problem cannot always understand the problem adequately. In order to deeply understand a problem, it is necessary that he/she poses various problems which can be solved by the “solution method” of the problem. Moreover, after he/she poses problems, it is necessary that he/she considers and indicates differences between the problems posed by him/her, too. So, we develop...

Spanning 30 years and 40 individual videogames across a range of platforms, Pac-Man is one of the most recognizable of all videogame characters and a pop–culture icon. In spite of its widespread popularity, the game receives little sustained academic engagement or analysis. In an attempt to address this, the paper argues that in its classic iterations PacMan generates complex notions of space a...

Paralinguistics organizers such as parenthesis, footnotes, and pop-up fields on screen, should play an important role signalling the writer’s “minimization” intention when secondary points are concerned. This experiment investigated the role of pop-up fields compared to brackets in an information retrieval task. The results showed that, in this kind of task, putting secondary pieces of informat...