OBJECTIVES To investigate the nature and cause in eight black South African patients of a recurrent (multiphasic), remitting, and relapsing demyelinating disease of the CNS. METHODS The clinical and laboratory investigations and radiological manifestations of these patients were documented. RESULTS Each patient had two or more acute attacks of demyelinating disease affecting the CNS. The cl...

INTRODUCTION There is paucity of data on acute disseminated encephalomyelitis (ADEM) in adults in India. Recent reports indicate that demyelinating disorders in the eastern hemisphere are quite distinct from conventional western type multiple sclerosis. AIMS This study aimed to study the clinical profile, laboratory and imaging parameters, in-hospital morbidity/ mortality and clinical and ima...

OBJECTIVE To describe a child with apparent brain biopsy-confirmed acute disseminated encephalomyelitis (ADEM) but genetic confirmation of compound heterozygosity for DNA mutations of the polymerase gamma (POLG) gene. DESIGN Case report. SETTING Tertiary referral center. PATIENT A 4-year-old boy presented with ataxia and encephalopathy. RESULTS Magnetic resonance imaging demonstrated mu...

Background: Acute disseminated encephalomyelitis (ADEM), which occurs spontaneously or after systemic viral infection and vaccination mostly affects children. This study aims at describing the epidemiologic, clinical, neuroimaging, laboratory features, treatment and outcome in children who diagnosed as having ADEM and admitted in a referral center in Tehran. Methods: This descriptive prospectiv...

BACKGROUND AND PURPOSE The degree to which MR imaging is useful in the diagnosis of MS is predicated on standardized and reliable evaluation of MR imaging parameters. We aimed to devise items for an MR imaging scoring tool that would have high inter-rater agreement and would be straightforward to apply. MATERIALS AND METHODS On the basis of a literature search and consensus of an expert panel...

background: acute disseminated encephalomyelitis ( adem), which occurs spontaneously or after systemic viral infection and vaccination mostly affects children. this study aims at describing the epidemiologic, clinical, neuroimaging, laboratory features, treatment and outcome in children who diagnosed as having adem and admitted in a referral center in tehran.   methods: this descriptive prospec...