BACKGROUND Repeated qualitative fecal immunochemical test (qlFIT) is a clinical strategy widely used to detect lower gastrointestinal lesions, but its diagnostic power has not been assessed in opportunistic screening for colorectal neoplasia. OBJECTIVE This study aimed to determine the performance of three-sample qlFIT in screening for colorectal cancer and its precursors in high-risk partici...

BACKGROUND Endometrial stromal tumours with sex-cord-like elements were first described by Clement and Scully in 1976. The recent World Health Organisation classification 2003 recognises low grade stromal sarcoma and undifferentiated endometrial sarcoma. CASE PRESENTATION A 62-year-old caucasian woman presented with recurrent postmenopausal bleeding. She underwent a diagnostic hysteroscopy wh...

Mutations in the adenomatous polyposis coli (APC) gene are linked to polyp formation in familial and sporadic colon cancer, but the functions of the protein are not known. We show that APC protein localizes mainly to clusters of puncta near the ends of microtubules that extend into actively migrating regions of epithelial cell membranes. This subcellular distribution of APC protein requires mic...

Adenomatous polyps in the colon have a high probability of developing into subsequent colorectal carcinoma, the second leading cause of cancer deaths in United States. In this paper, we propose a new method for computer-aided diagnosis of polyps. Initial work with shape detection has shown high sensitivity for polyp detection, but at a cost of too many false positive detections. We present a st...

Benign polyps of the stomach undergo malignant transformation at a rate correlating to the histological type and size of the proliferative lesion. We report a case of a 50-year-old Caucasian woman, affected by a diffuse gastric polyposis of both hyperplastic and adenomatous type. At endoscopy polyps were more than 1,000, scattered over the entire gastric cavity. The patient underwent total gast...

Background: In western countries with high prevalence of colorectal cancers, colonic polyps are usually adenomatous. There are few studies from Iran regarding to the predominant type of polyps in colorectal area. Objectives: We conducted this retrospective study to evaluate the predominant colorectal polyps in our center as the largest referral center of the South region of Iran. Material and M...

The finding of adenomatous polyps of the gallbladder is a rare occurrence and an unusual clinical problem. Among 2,145 patients who underwent cholecystectomy for gallbladder disease only 9 (0.4 per cent) presented with adenomatous polyps. There were 6 women and 3 men, aged 17 to 70 years. Preoperative ultrasonographic diagnosis was made in only 1 of 7 patients with gallstones, in contrast polyp...

Familial adenomatous polyposis ia an autosomal dominant disorder that is responsible for 0.5% of all colorectal cancer. Patients will develop hundreds to thousands of colonic polyp in their second decades of life. The life time risk of developing colorectal cancer is 100% at the median age of 39 years. Extra intestinal manifestations are rare and mostly are benign. Family history of colorectal ...

Background MUTYH-associated polyposis (MAP) is an autosomal recessive disorder that is caused by germline mutations in the base excision repair gene MUTYH. Phenotypic expression is usually that of an attenuated polyposis syndrome with anywhere from 3-100+ polyps and mixed pathology including tubular adenomas, sessile serrated adenomas, and/or hyperplastic polyps. The use of nonsteroidal anti-in...

Dietary fat intake and cancer risk have been investigated in detail in many populations, although the results have been inconsistent for colorectal cancer. Several molecular mechanisms have been proposed to explain how specific dietary fatty acids could alter colorectal cancer risk due to their involvement in varying physiologic functions (1). These include apoptosis, inflammation, cell prolife...