We describe conditions for producing uninterrupted expanded CTG repeats consisting of up to 2000 repeats using 29 DNA polymerase. Previously, generation of such repeats was hindered by CTG repeat instability in plasmid vectors maintained in Escherichia coli and poor in vitro ligation of CTG repeat concatemers due to strand slippage. Instead, we used a combination of in vitro ligation and 29 DNA...

Bu araştırmada spor yapan ve yapmayan lise öğrencilerinin benlik saygısının bireysel sorumluluk düzeylerine etkisinin incelenmesi amaçlanmıştır. Araştırmanın örneklem grubunu Balıkesir ilinin Karesi Altıeylül merkez ilçelerinde bulunan dört farklı türdeki ortaöğretim kurumlarında öğrenim gören 238’i erkek, 355’i kız olmak üzere toplam 593 Öğrenci oluşturmaktadır. Veri toplama aracı olarak araşt...

We study methods for solving the Cauchy problem for systems of non-linear hyperbolic balance laws with initial condition consisting of two smooth vectors, with a discontinuity at the origin. We call this initial-value problem the Derivative Riemann Problem, or DRP. Two new methods of solution are presented. The first one results from a re-interpretation of the high-order numerical methods propo...

This paper deals with the numerical modeling of transient mechanical waves in linear viscoelastic solids. Dissipation mechanisms are described using the generalized Zener model. No time convolutions are required thanks to the introduction of memory variables that satisfy local-in-time differential equations. By appropriately choosing the relaxation parameters, it is possible to accurately descr...

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