Dendrite ramification affects synaptic strength and plays a crucial role in memory. Previous studies revealed a correlation between beta 2-adrenergic receptor dysfunction and Alzheimer's disease (AD), although the mechanism involved is still poorly understood. The current study investigated the potential effect of the selective β2-adrenergic receptor antagonist, ICI 118551 (ICI), on Aβ deposits...

BACKGROUND In this work, effect of Tamsulosin hydrochloride as antagonist of alpha1A and alpha1B- adrenergic receptor and effect of Salbutamol as agonist of beta2- adrenergic receptor in patients with bronchial asthma and increased bronchial reactibility was studied. METHODS Parameters of the lung function are determined by Body plethysmography. Raw and ITGV were registered and specific resis...

Background—Autoantibodies against synthetic peptides of b-adrenergic receptors have been observed in human cardiomyopathy. However, it has never been shown that such antibodies really interact with native human b-adrenergic receptors, nor has the clinical impact of such an interaction been investigated in larger groups of patients. Methods and Results—We screened 104 patients with dilated or is...

BACKGROUND Mammalian receptors that couple to effectors via heterotrimeric G proteins (e.g., beta 2-adrenergic receptors) and receptors with intrinsic tyrosine kinase activity (e.g., insulin and IGF-I receptors) constitute the proximal points of two dominant cell signaling pathways. Receptors coupled to G proteins can be substrates for tyrosine kinases, integrating signals from both pathways. Y...

background α-adrenergic receptor 2a (adra2a) and angiotensin-converting enzyme (ace) genes have been variably associated with obesity and its related phenotypes in different populations worldwide. objectives this cross-sectional study aims to investigate the association of adrenergic receptor α2a (adra2a) rs553668 and angiotensin-converting enzyme (ace) i/d single nucleotide polymorphisms (snps...

Propranolol is a nonselective beta-adrenergic receptor blocking agent possessing no other autonomic nervous system activity. It specifically competes with beta-adrenergic receptor agonist agents for available receptor sites. When access to beta-receptor sites is blocked by propranolol, the chronotropic, inotropic, and vasodilator responses to beta-adrenergic stimulation are decreased proportion...

Introduction: Malignant astrocytic gliomas are the most common and lethal brain malignancies due to their refractory to the current therapies. Nowadays, molecular targeted therapy has attracted great attention in treatment of glioma. Connexin 43 (Cx43) and micro ribonucleic acid- 21(miR-21) are among molecules that are involved in glioma development and progression. These molecules showed...