نتایج جستجو برای: adrenoreceptor
تعداد نتایج: 874 فیلتر نتایج به سال:
Usage of cyclosporine A (CsA) after kidney transplantation may be associated with development of nephrotoxicity and vasculopathy, but the mechanisms by which CsA causes vascular dysfunction are still under scrutiny. We established a transplantation model and investigated the effect of CsA on vascular contractility with the aid of a pressurized myograph in comparison with control and unilaterall...
Objective: To determine whether patients with congestive heart failure on different β adrenoreceptor blocking drugs have similar haemodynamic responses to dobutamine. Design: Single centre, single blind, randomised, two period crossover study comparing carvedilol with metoprolol CR/XL. Patients: Ten patients with stable chronic congestive heart failure (ejection fraction < 40%) on chronic treat...
Zahn, Sebastian, Stefan Leis, Christoph Schick, Martin Schmelz, and Frank Birklein. No -adrenoreceptor-induced C-fiber activation in healthy human skin. J Appl Physiol 96: 1380–1384, 2004. First published December 12, 2003; 10.1152/japplphysiol.00990.2003.—In healthy volunteers, flare responses induced by norepinephrine (NE) iontophoresis have been observed. However, as NE iontophoresis is a co...
Arg/Arg homozygotes for the Gly16Arg polymorphism in the β₂-adrenoreceptor gene (ADRB2) have a reduced response to short-acting β₂-agonists but no effect has been associated with long-acting β₂-agonists (LABAs). We selected 604 subjects with current asthma from the European Community Respiratory Health Study to evaluate whether asthma control and lung function decline were associated with Gly16...
BACKGROUND The role of noradrenergic system in the control of nociception is documented in some vertebrate animals. However, there are no data showing the role of this system on nociception in the marsh terrapins. METHODOLOGY In this study, the antinociceptive action of intrathecal administration of the α 2-adrenoreceptor agonist clonidine and α 2-adrenoreceptor antagonist yohimbine was evalu...
Dissecting out the Complex Ca2+-Mediated Phenylephrine-Induced Contractions of Mouse Aortic Segments
L-type Ca2+ channel (VGCC) mediated Ca2+ influx in vascular smooth muscle cells (VSMC) contributes to the functional properties of large arteries in arterial stiffening and central blood pressure regulation. How this influx relates to steady-state contractions elicited by α1-adrenoreceptor stimulation and how it is modulated by small variations in resting membrane potential (Vm) of VSMC is not ...
We investigated a possible involvement of the sympathetic nervous system in the parallel increase of renin, cyclooxygenase-2 (COX-2), and neuronal nitric oxide synthase (nNOS) gene expression in the juxtaglomerular apparatus of rat kidneys induced by salt deficiency. Therefore, we determined the effects of renal denervation and the beta-adrenoreceptor antagonist metoprolol (50 mg/kg body wt po,...
Jain, Felipe A., Long-hai Zhao, Martin K. Selig, and Richard L. Kradin. Epinephrine promotes pulmonary angiitis: evidence for a 1-adrenoreceptor-mediated mechanism. Am J Physiol Lung Cell Mol Physiol 285: L232–L239, 2003; 10.1152/ajplung.00248.2002.—Epinephrine (Epi) increases lymphocyte traffic to lung. We investigated whether Epi also modulates pulmonary cell-mediated immune responses in vivo...
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